Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.2.2

Official Name

gamma-glutamyltransferase

Name from literature

gamma glutamyl transferase

Pathway from literature

glutathione synthesis

Pathway from KEGG

Metabolism of Other Amino Acids; Glutathione metabolism; map00480

Metabolism of Other Amino Acids; Cyanoamino acid metabolism; map00460

Metabolism of Other Amino Acids; Selenoamino acid metabolism; map00450

Lipid Metabolism; Arachidonic acid metabolism; map00590

Metabolism of Other Amino Acids; Taurine and hypotaurine metabolism; map00430

Organisms

Rat (10116)

Genome localization

3q42[156275 ], 10q24[408206 ], -[29566 ], -[116568 ],

Rate-limiting Description

"Although aspects of the glutathione antioxidant repertoire were similarly diminished with high-intensity xanthine oxidase stress, low-dose (long duration) xanthine oxidase stress augmented the activities of type II cell glutathione peroxidase and gamma-glutamyl transferase (the rate-limiting enzyme in glutathione synthesis)." (12780970)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q99MZ4:from_uniprot:83_Phosphoserine

Gene ontology

Gene ontology

GO:0008415 (F) acyltransferase activity [Q9QWE9, Q99MZ4, Q6IE08, P07314 ];
GO:0003840 (F) gamma-glutamyltransferase activity [Q9QWE9, Q99MZ4, Q6IE08, P07314 ];
GO:0016021 (C) integral to membrane [Q9QWE9, Q99MZ4, Q6IE08, P07314 ];
GO:0006750 (P) glutathione biosynthetic process [Q9QWE9, Q99MZ4, Q6IE08, P07314 ];
GO:0019370 (P) leukotriene biosynthetic process [Q9QWE9 ];

Subcellular localization

Localization

cell membrane [Q9QWE9, Q99MZ4, Q6IE08, P07314 ];

Links

SwissProt

P07314; Q6IE08; Q99MZ4; Q9QWE9

Entrez Gene

116568; 156275; 29566; 408206



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min