Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.2.2

Official Name

gamma-glutamyltransferase

Name from literature

gamma glutamyl transferase

Pathway from literature

glutathione synthesis

Pathway from KEGG

Metabolism of Other Amino Acids; Glutathione metabolism; map00480

Metabolism of Other Amino Acids; Cyanoamino acid metabolism; map00460

Metabolism of Other Amino Acids; Selenoamino acid metabolism; map00450

Lipid Metabolism; Arachidonic acid metabolism; map00590

Metabolism of Other Amino Acids; Taurine and hypotaurine metabolism; map00430

Organisms

Mouse (10090)

Genome localization

10 C1[14598 ], 11 B4[71522 ], 10 C1[23887 ], 2 H1[207182 ],

Rate-limiting Description

"Although aspects of the glutathione antioxidant repertoire were similarly diminished with high-intensity xanthine oxidase stress, low-dose (long duration) xanthine oxidase stress augmented the activities of type II cell glutathione peroxidase and gamma-glutamyl transferase (the rate-limiting enzyme in glutathione synthesis)." (12780970)

"The increase in activity of both GPX and GST corresponded with increased transcription of these enzymes, as well as the rate-limiting enzyme in GSH synthesis, gamma-glutamyl transferase." (15006645)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q99JP7

phosphorylation;

Q99JP7:from_uniprot:83_Phosphoserine

Gene ontology

Gene ontology

GO:0006954 (P) inflammatory response [Q9Z2A9 ];
GO:0005886 (C) plasma membrane [Q9Z2A9 ];
GO:0019370 (P) leukotriene biosynthetic process [Q9Z2A9 ];
GO:0003840 (F) gamma-glutamyltransferase activity [Q60928, Q99JP7, Q9Z2A9, Q6PDE7 ];
GO:0008415 (F) acyltransferase activity [Q60928, Q99JP7, Q9Z2A9, Q6PDE7 ];
GO:0005887 (C) integral to plasma membrane [Q60928 ];
GO:0006750 (P) glutathione biosynthetic process [Q60928, Q99JP7, Q9Z2A9, Q6PDE7 ];
GO:0016021 (C) integral to membrane [Q99JP7, Q9Z2A9, Q6PDE7 ];
GO:0007283 (P) spermatogenesis [Q60928 ];

Subcellular localization

Localization

cell membrane [Q60928, Q99JP7, Q9Z2A9, Q6PDE7 ];

Disease relevance

Disease

Defects in Ggt1 are a cause of glutathionuria, severe growth failure, reduced life spans and infertility. Ggt1-deficient mice have multiple metabolic abnormalities and are dwarf. Some abnormalities can be ameliorated by N-acetylcysteine treatment [Q60928 ];

Links

SwissProt

Q60928; Q6PDE7; Q99JP7; Q9Z2A9

Entrez Gene

14598; 207182; 23887; 71522



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min