Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.15

Official Name

glycerol-3-phosphate O-acyltransferase

Name from literature

sn glycerol phosphate acyl transferase

Pathway from literature

Pathway from KEGG

Lipid Metabolism; Glycerolipid metabolism; map00561

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Rat (10116)

Genome localization

1q55[29653 ],

Comments

Acyl-[acyl-carrier protein] can also act as acyl donor. The enzyme acts only on derivatives of fatty acids of chain length above C10

Rate-limiting Description

"Glycerol-3-phosphate acyltransferase (GPAT) represents the first committed step and probably the rate limiting step in glycerolipid synthesis and thus may be a good candidate for study." (2303421)

"It is concluded that, at optimum substrate concentrations, the activity of glycerol phosphate acyltransferase is rate-limiting in the synthesis of phosphatidate by rat liver microsomal fractions." (813635)

"When activated, AMPK increases fatty acid oxidation by inhibiting acetyl-CoA carboxylase (ACC) and reducing malonyl-CoA levels, and it decreases TG content by inhibiting glycerol-3-phosphate acyltransferase (GPAT), the rate-limiting step in TG synthesis." (12464581)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P97564

phosphorylation;

P97564:from_uniprot:111_Phosphotyrosine

phosphorylation;

P97564:from_uniprot:695_Phosphoserine

phosphorylation;

"TXow mitochondrial isoforms have been identified, one being sensitive in phosphorylation in vitro." (16431156)

Gene ontology

Gene ontology

GO:0008654 (P) phospholipid biosynthetic process [P97564 ];
GO:0016021 (C) integral to membrane [P97564 ];
GO:0005741 (C) mitochondrial outer membrane [P97564 ];
GO:0004366 (F) glycerol-3-phosphate O-acyltransferase acti... [P97564 ];

Subcellular localization

Localization

mitochondrion [P97564 ];

Links

SwissProt

P97564

Entrez Gene

29653



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  Last Modified: 2009-03-24  
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