Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.15

Official Name

glycerol-3-phosphate O-acyltransferase

Name from literature

sn glycerol phosphate acyl transferase

Pathway from literature

Pathway from KEGG

Lipid Metabolism; Glycerolipid metabolism; map00561

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Mouse (10090)

Genome localization

19 D2|19 52.0 cM[14732 ],

Comments

Acyl-[acyl-carrier protein] can also act as acyl donor. The enzyme acts only on derivatives of fatty acids of chain length above C10

Rate-limiting Description

"Acyl-CoA:monoacylglycerol acyltransferase (MGAT) plays an important role in dietary fat absorption by catalyzing a rate-limiting step in the re-synthesis of diacylglycerols in enterocytes." (12730219)

"Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step of glycerolipid synthesis." (14724270)

Regulatory Information

Upstream transcription factor

22278;20787

Regulatory type

Detail

phosphorylation;

Q61586

phosphorylation;

Q61586:from_uniprot:111_Phosphotyrosine

phosphorylation;

Q61586:from_uniprot:694_Phosphoserine

transcriptional factor;USF-1(22278),SREBP-1(20787)

"Upstream stimulating factor-1 (USF-1) controlled both promoters whereas sterol regulatory element-binding protein-1 (SREBP-1) exclusively regulated promoter 1a activity in vitro." (18983939)

Gene ontology

Gene ontology

GO:0006631 (P) fatty acid metabolic process [Q61586 ];
GO:0008654 (P) phospholipid biosynthetic process [Q61586, Q14DK4 ];
GO:0016021 (C) integral to membrane [Q61586, Q14DK4 ];
GO:0005743 (C) mitochondrial inner membrane [Q61586 ];
GO:0005741 (C) mitochondrial outer membrane [Q61586 ];
GO:0040018 (P) positive regulation of multicellular organi... [Q61586 ];
GO:0004366 (F) glycerol-3-phosphate O-acyltransferase acti... [Q61586, Q14DK4 ];

Subcellular localization

Localization

mitochondrion [Q61586 ];

membrane [Q14DK4 ];

Links

SwissProt

Q14DK4; Q61586

Entrez Gene

14732



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  Last Modified: 2009-03-24  
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