Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.4.1.143

Official Name

alpha-1,6-mannosyl-glycoprotein

Name from literature

beta1 n acetylglucosaminyltransferase

Pathway from literature

synthesis of selectin ligands

Pathway from KEGG

Glycan Biosynthesis and Metabolism; N-Glycan biosynthesis; map00510

Glycan Biosynthesis and Metabolism; Glycan structures - Biosynthesis 1; map01030

Organisms

Mouse (10090)

Genome localization

12 C2[217664 ],

Comments

R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor. Note that this enzyme acts after N-acetylglucosaminyltransferase I but before N-acetylglucosaminyltransferases III, IV, V and VI (click here for diagram).

Rate-limiting Description

"Associations linking the importance of glycosylation events to tumor biology, especially the progression to metastatic disease, have been noted over many years, Recently, a mouse model in which beta1,6-N-acetylglucosaminyltransferase V (a rate-limiting enzyme in the N-glycan pathway) has been knocked out, was used to demonstrate the importance of glycosylation in tumor progression." (11250723)

Gene ontology

Gene ontology

GO:0005795 (C) Golgi stack [Q921V5 ];
GO:0018279 (P) protein amino acid N-linked glycosylation v... [Q921V5 ];
GO:0016021 (C) integral to membrane [Q921V5 ];
GO:0009312 (P) oligosaccharide biosynthetic process [Q921V5 ];
GO:0008455 (F) alpha-1, 6-mannosylglycoprotein 2-beta-N-ace... [Q921V5 ];
GO:0000139 (C) Golgi membrane [Q921V5 ];

Subcellular localization

Localization

golgi apparatus [Q921V5 ];

membrane [Q921V5 ];

Links

SwissProt

Q921V5

Entrez Gene

217664



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  Last Modified: 2009-03-24  
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