Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.3.99.2

Official Name

butyryl-CoA dehydrogenase

Name from literature

medium chain acyl coA dehydrogenase

Pathway from literature

medium-chain fatty acid beta-oxidation

Pathway from KEGG

Lipid Metabolism; Fatty acid metabolism; map00071

Amino Acid Metabolism; Valine, leucine and isoleucine degradation; map00280

Carbohydrate Metabolism; Butanoate metabolism; map00650

Organisms

Mouse (10090)

Genome localization

5 F|5 65.0 cM[11409 ],

Comments

A flavoprotein; forms, with another flavoprotein ('electron-transferring flavoproteins') and EC 1.5.5.1 electron-transferring-flavoprotein dehydrogenase, a system reducing ubiquinone and other acceptors.

Rate-limiting Description

"Results of RV pressure overload studies in mice transgenic for the promoter region of the gene encoding human medium-chain acyl-CoA dehydrogenase (MCAD, which catalyzes a rate-limiting step in the FAO cycle) fused to a chloramphenicol acetyltransferase reporter confirmed that repression of MCAD gene expression in the hypertrophied ventricle occurred at the transcriptional level." (9177236)

Gene ontology

Gene ontology

GO:0050660 (F) FAD binding [Q07417 ];
GO:0006631 (P) fatty acid metabolic process [Q07417 ];
GO:0009055 (F) electron carrier activity [Q07417 ];
GO:0005759 (C) mitochondrial matrix [Q07417 ];
GO:0055114 (P) oxidation reduction [Q07417 ];
GO:0004085 (F) butyryl-CoA dehydrogenase activity [Q07417 ];

Subcellular localization

Localization

mitochondrion [Q07417 ];

Links

SwissProt

Q07417

Entrez Gene

11409



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  Last Modified: 2009-03-24  
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