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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 1.3.1.2 |
Official Name | dihydropyrimidine dehydrogenase (NADP+) |
Name from literature | dihydropyrimidine dehydrogenase |
Pathway from literature | 5-fluorouracil (5-FU) chemotherapy catabolic pathway |
Pathway from KEGG |
Metabolism of Other Amino Acids; beta-Alanine metabolism; map00410 |
Xenobiotics Biodegradation and Metabolism; Drug metabolism - other enzymes; map00983 | |
Nucleotide Metabolism; Pyrimidine metabolism; map00240 | |
Organisms | Rat (10116) |
Genome localization | 2q41[81656 ], |
Comments | Also acts on dihydrothymine. |
Rate-limiting Description | "In the present study, the influence of liver damage induced by bile duct ligation on dihydropyrimidine dehydrogenase (DPD), a rate-limiting enzyme in 5-FU catabolism, CYP2B, and 5-FU pharmacokinetics were compared in male Sprague-Dawley rats." (10348793) |
Regulatory Information |
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Regulatory type | Detail |
phosphorylation; | O89000:from_uniprot:577_Phosphoserine |
Gene ontology |
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Gene ontology |
GO:0050661 (F) NADP binding [O89000 ]; |
Subcellular localization |
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Localization |
cytoplasm [O89000 ]; |
Links |
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SwissProt | |
Entrez Gene |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |