Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.3.1.2

Official Name

dihydropyrimidine dehydrogenase (NADP+)

Name from literature

dihydropyrimidine dehydrogenase

Pathway from literature

5-fluorouracil (5-FU) chemotherapy catabolic pathway

Pathway from KEGG

Metabolism of Other Amino Acids; beta-Alanine metabolism; map00410

Xenobiotics Biodegradation and Metabolism; Drug metabolism - other enzymes; map00983

Nucleotide Metabolism; Pyrimidine metabolism; map00240

Organisms

Rat (10116)

Genome localization

2q41[81656 ],

Comments

Also acts on dihydrothymine.

Rate-limiting Description

"In the present study, the influence of liver damage induced by bile duct ligation on dihydropyrimidine dehydrogenase (DPD), a rate-limiting enzyme in 5-FU catabolism, CYP2B, and 5-FU pharmacokinetics were compared in male Sprague-Dawley rats." (10348793)

Regulatory Information

Regulatory type

Detail

phosphorylation;

O89000:from_uniprot:577_Phosphoserine

Gene ontology

Gene ontology

GO:0050661 (F) NADP binding [O89000 ];
GO:0006207 (P) 'de novo' pyrimidine base biosynthetic process [O89000 ];
GO:0042803 (F) protein homodimerization activity [O89000 ];
GO:0051539 (F) 4 iron, 4 sulfur cluster binding [O89000 ];
GO:0005829 (C) cytosol [O89000 ];
GO:0005506 (F) iron ion binding [O89000 ];
GO:0017113 (F) dihydropyrimidine dehydrogenase (NADP+) act... [O89000 ];
GO:0004158 (F) dihydroorotate oxidase activity [O89000 ];
GO:0009055 (F) electron carrier activity [O89000 ];
GO:0006212 (P) uracil catabolic process [O89000 ];
GO:0006214 (P) thymidine catabolic process [O89000 ];
GO:0055114 (P) oxidation reduction [O89000 ];

Subcellular localization

Localization

cytoplasm [O89000 ];

Links

SwissProt

O89000

Entrez Gene

81656



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  Last Modified: 2009-03-24  
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