Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.5

Official Name

arylamine N-acetyltransferase

Name from literature

N-acetyltransferase

Pathway from literature

melatonin synthesis

Pathway from KEGG

Xenobiotics Biodegradation and Metabolism; Drug metabolism - other enzymes; map00983

Biosynthesis of Secondary Metabolites; Caffeine metabolism; map00232

Xenobiotics Biodegradation and Metabolism; Trinitrotoluene degradation; map00633

Organisms

Rat (10116)

Genome localization

16p14[290681 ], 16p14[116631 ], 16p14[116632 ],

Comments

Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA.

Rate-limiting Description

"In our previous studies, the opioid receptors located on pinealocytes have been identified and characterized, and these receptors have been found to play a stimulatory role in melatonin synthesis by activating the rate limiting enzyme, N-acetyltransferase (NAT)." (10471401)

"Detailed investigations with chemically induced mammary tumors in rats and serial transplants derived thereof show that slow-growing and well-differentiated tumors containing epithelial cell elements (adenocarcinomas and carcinosarcomas) lead to an enhanced production of melatonin involving activation of the rate-limiting enzyme of pineal melatonin biosynthesis (serotonin N-acetyltransferase) probably due to elevation of the sympathetic tone in response to a stimulation of the cellular immune system by malignant growth." (10721063)

"Caffeine, an important member of methylxanthines, induced a prolonged nocturnal rise in pineal melatonin content and an increase in its rate-limiting enzyme serotonin N-acetyltransferase (NAT) activity." (10467435)

Regulatory Information

Upstream transcription factor

290215;29663

Regulatory type

Detail

phosphorylation;

P50298:from_uniprot:246_Phosphotyrosine

transcriptional factor;AP-1(171494,29663,360785,290215,306332)

"Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock's zeitgebers." (10987819)

Gene ontology

Gene ontology

GO:0004060 (F) arylamine N-acetyltransferase activity [Q45G71, P50298, Q4F8Y7, P50297, Q45G59, Q80SX3 ];
GO:0005737 (C) cytoplasm [P50298, P50297 ];
GO:0008152 (P) metabolic process [Q45G71, P50298, Q4F8Y7, P50297, Q45G59, Q80SX3 ];

Subcellular localization

Localization

cytoplasm [P50298, P50297 ];

Links

SwissProt

P50297; P50298; Q45G59; Q45G71; Q4F8Y7; Q80SX3

Entrez Gene

116631; 116632; 290681



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min