Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.11

Official Name

6-phosphofructokinase

Name from literature

phosphofructokinase

Pathway from literature

glycolysis

Pathway from KEGG

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Carbohydrate Metabolism; Fructose and mannose metabolism; map00051

Carbohydrate Metabolism; Pentose phosphate pathway; map00030

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Carbohydrate Metabolism; Galactose metabolism; map00052

Organisms

Rat (10116)

Genome localization

20p12[25741 ], 7q36[65152 ],

Comments

D-Tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors. UTP, CTP and ITP can act as donors. Not identical with EC 2.7.1.105 6-phosphofructo-2-kinase.

Rate-limiting Description

"Microarrays and RNAse protection assays were used to assess the expression of several electron transport chain components (cytochrome-c oxidase subunits Cox 5A, Cox 5B, and Cox 6A, ATP synthase, and ATP synthase subunit 5B) and of the rate-limiting enzyme for glycolysis, phosphofructokinase (PFK)." (16103521)

Regulatory Information

Upstream transcription factor

171302

Regulatory type

Detail

phosphorylation;

P30835

phosphorylation;

P47860

phosphorylation;

P30835:from_uniprot:640_Phosphotyrosine

phosphorylation;

P47858:from_uniprot:2_Phosphothreonine

phosphorylation;

P47858:from_uniprot:775_Phosphoserine

phosphorylation;

P47860:from_uniprot:386_Phosphoserine

phosphorylation;

P47860:from_uniprot:651_Phosphotyrosine

transcriptional factor;HNF-3(171302)

"In contrast with the lack of effect of glucocorticoids on factor binding to constitutively open GRUs of other genes, HNF-3 binding to the open PFK-2 GRU was hormone-dependent." (9212165)

transcriptional level;TNF

"TNF did not induce any change on the activities of glucokinase, hexokinase, pyruvate kinase and glucose-6-phosphate dehydrogenase, although significant increase in the activity of muscle phosphofructokinase was observed." (8358332)

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [P47860, P47858, P30835 ];
GO:0005945 (C) 6-phosphofructokinase complex [P47860, P47858, P30835 ];
GO:0003872 (F) 6-phosphofructokinase activity [P47860, P47858, P30835 ];
GO:0006096 (P) glycolysis [P47860, P47858, P30835 ];
GO:0006002 (P) fructose 6-phosphate metabolic process [P30835 ];
GO:0005524 (F) ATP binding [P47860, P47858, P30835 ];

Links

SwissProt

P30835; P47858; P47860

Entrez Gene

25741; 65152



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  Last Modified: 2009-03-24  
  Design by Zhao Min