Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.11

Official Name

6-phosphofructokinase

Name from literature

phosphofructokinase

Pathway from literature

glycolysis

Pathway from KEGG

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Carbohydrate Metabolism; Fructose and mannose metabolism; map00051

Carbohydrate Metabolism; Pentose phosphate pathway; map00030

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Carbohydrate Metabolism; Galactose metabolism; map00052

Organisms

E.coli (83333)

Genome localization

-[948412 ], -[946230 ],

Comments

D-Tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors. UTP, CTP and ITP can act as donors. Not identical with EC 2.7.1.105 6-phosphofructo-2-kinase.

Rate-limiting Description

"Alterations in the level of ATP apparently affect the velocity of phosphofructokinase, the rate-limiting enzyme in glycolsis, altering the cellular levels of glucose-6-P or fructose-P2." (1100623)

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [P0A796 ];
GO:0005945 (C) 6-phosphofructokinase complex [P0A796 ];
GO:0003872 (F) 6-phosphofructokinase activity [P06999, P0A796 ];
GO:0006096 (P) glycolysis [P06999, P0A796 ];
GO:0006002 (P) fructose 6-phosphate metabolic process [P0A796 ];
GO:0005515 (F) protein binding [P0A796 ];
GO:0005524 (F) ATP binding [P0A796 ];

Subcellular localization

Localization

cytoplasm [P0A796 ];

Links

SwissProt

P06999; P0A796

Entrez Gene

946230; 948412



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  Last Modified: 2009-03-24  
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