Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.20

Official Name

diacylglycerol O-acyltransferase

Name from literature

diacylglycerol acyltransferase

Pathway from literature

diacylglycerol conversion to triacylglycerol

Pathway from KEGG

Lipid Metabolism; Glycerolipid metabolism; map00561

Metabolism of Cofactors and Vitamins; Retinol metabolism; map00830

Organisms

Rat (10116)

Genome localization

7q34[84497 ], 1q32[252900 ],

Comments

Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.

Rate-limiting Description

"The rate-limiting role of diacylglycerol acyltransferase." (2737209)

"Rat liver acyl coenzyme A:diacylglycerol acyltransferase, an intrinsic membrane activity associated with the endoplasmic reticulum, catalyzes the terminal and rate-limiting step in triglyceride synthesis." (2559137)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q9ERM3:from_uniprot:20_Phosphoserine

Gene ontology

Gene ontology

GO:0030073 (P) insulin secretion [Q91YB5 ];
GO:0005504 (F) fatty acid binding [Q91YB5 ];
GO:0019992 (F) diacylglycerol binding [Q91YB5 ];
GO:0019432 (P) triacylglycerol biosynthetic process [Q91YB5 ];
GO:0004144 (F) diacylglycerol O-acyltransferase activity [Q9ERM3, Q5FVP8, Q91YB5 ];
GO:0005789 (C) endoplasmic reticulum membrane [Q9ERM3, Q5FVP8 ];
GO:0006071 (P) glycerol metabolic process [Q5FVP8 ];
GO:0016021 (C) integral to membrane [Q9ERM3, Q5FVP8 ];
GO:0005792 (C) microsome [Q91YB5 ];

Subcellular localization

Localization

endoplasmic reticulum [Q9ERM3, Q5FVP8 ];

Links

SwissProt

Q5FVP8; Q91YB5; Q9ERM3

Entrez Gene

252900; 84497



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  Last Modified: 2009-03-24  
  Design by Zhao Min