Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.4.14.5

Official Name

dipeptidyl-peptidase IV

Name from literature

dipeptidyl peptidase

Pathway from literature

the hydrolysis of the alanine substrates

Organisms

Rat (10116)

Genome localization

3q21[25253 ], 9q11[301130 ], 8q24[315758 ],

Comments

A homodimer. An integral protein of the plasma membrane of lymphocytes and other mammalian cells, in peptidase family S9 (prolyl oligopeptidase family). The reaction is similar to that of the unrelated EC 3.4.14.11 Xaa-Pro dipeptidyl-peptidase of lactococci

Rate-limiting Description

"Moreover, as estimated from the residual peptide structure and confirmed by exogenous peptidase supplementation, dipeptidyl peptidase IV and dipeptidyl carboxypeptidase I were identified as the rate-limiting enzymes in the digestive breakdown of these peptides." (12223360)

Gene ontology

Gene ontology

GO:0004177 (F) aminopeptidase activity [P14740 ];
GO:0016021 (C) integral to membrane [P14740 ];
GO:0006508 (P) proteolysis [P14740 ];
GO:0005576 (C) extracellular region [P14740 ];
GO:0005886 (C) plasma membrane [P14740 ];
GO:0004252 (F) serine-type endopeptidase activity [P14740 ];

Subcellular localization

Localization

extracellular [P14740 ];

cell membrane [P14740 ];

Links

SwissProt

P14740

Entrez Gene

25253; 301130; 315758



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  Last Modified: 2009-03-24  
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