Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

Official Name

dipeptidyl-peptidase IV

Name from literature

dipeptidyl peptidase

Pathway from literature

the hydrolysis of the alanine substrates


Rat (10116)

Genome localization

3q21[25253 ], 9q11[301130 ], 8q24[315758 ],


A homodimer. An integral protein of the plasma membrane of lymphocytes and other mammalian cells, in peptidase family S9 (prolyl oligopeptidase family). The reaction is similar to that of the unrelated EC Xaa-Pro dipeptidyl-peptidase of lactococci

Rate-limiting Description

"Moreover, as estimated from the residual peptide structure and confirmed by exogenous peptidase supplementation, dipeptidyl peptidase IV and dipeptidyl carboxypeptidase I were identified as the rate-limiting enzymes in the digestive breakdown of these peptides." (12223360)

Gene ontology

Gene ontology

GO:0004177 (F) aminopeptidase activity [P14740 ];
GO:0016021 (C) integral to membrane [P14740 ];
GO:0006508 (P) proteolysis [P14740 ];
GO:0005576 (C) extracellular region [P14740 ];
GO:0005886 (C) plasma membrane [P14740 ];
GO:0004252 (F) serine-type endopeptidase activity [P14740 ];

Subcellular localization


extracellular [P14740 ];

cell membrane [P14740 ];




Entrez Gene

25253; 301130; 315758

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  Last Modified: 2009-03-24  
  Design by Zhao Min