Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.9

Official Name

acetyl-CoA C-acetyltransferase

Name from literature

acetyl coA acetyltransferase

Pathway from literature

Pathway from KEGG

Lipid Metabolism; Fatty acid metabolism; map00071

Lipid Metabolism; Synthesis and degradation of ketone bodies; map00072

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Carbohydrate Metabolism; Propanoate metabolism; map00640

Xenobiotics Biodegradation and Metabolism; Benzoate degradation via CoA ligation; map00632

Environmental Information Processing; Signal Transduction; Two-component system; map02020

Amino Acid Metabolism; Tryptophan metabolism; map00380

Amino Acid Metabolism; Valine, leucine and isoleucine degradation; map00280

Amino Acid Metabolism; Lysine degradation; map00310

Carbohydrate Metabolism; Butanoate metabolism; map00650

Organisms

Rat (10116)

Genome localization

8q24.1[25014 ],

Rate-limiting Description

"The influence of clofibrate and di(2-ethylhexyl)phthalate on mitochondrial acetyl-CoA acetyltransferase (acetyl-CoA: acetyl-CoA C-acetyltransferase, EC 2.3.1.9), the rate-limiting ketogenic enzyme, which can be modified and inactivated by CoA, was investigated." (2869784)

Gene ontology

Gene ontology

GO:0003985 (F) acetyl-CoA C-acetyltransferase activity [Q5XI22, P83144, P17764 ];
GO:0019408 (P) dolichol biosynthetic process [P83144 ];
GO:0005777 (C) peroxisome [P83144 ];
GO:0005737 (C) cytoplasm [Q5XI22 ];
GO:0006695 (P) cholesterol biosynthetic process [P83144 ];
GO:0008152 (P) metabolic process [Q5XI22, P17764 ];

Subcellular localization

Localization

mitochondrion [P17764 ];

cytoplasm [Q5XI22 ];

Links

SwissProt

P17764; P83144; Q5XI22

Entrez Gene

25014



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  Last Modified: 2009-03-24  
  Design by Zhao Min