Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.4.11.7

Official Name

glutamyl aminopeptidase

Name from literature

aminopeptidase a

Pathway from literature

angiotensin degradation

Pathway from KEGG

Cellular Processes; Endocrine System; Renin - angiotensin system; map04614

Organisms

Mouse (10090)

Genome localization

3 G3|3 65.2 cM[13809 ],

Comments

Ca2+-activated and generally membrane-bound. A zinc-metallopeptidase in family M1 (membrane alanyl aminopeptidase family)

Rate-limiting Description

"Aminopeptidase A (APA, EC 3.4.11.7) is responsible for the N-terminal cleavage of AngII, a hydrolytic event that serves as a rate-limiting step in angiotensin degradation." (12765341)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P16406:from_uniprot:12_Phosphotyrosine

Gene ontology

Gene ontology

GO:0009897 (C) external side of plasma membrane [P16406 ];
GO:0008270 (F) zinc ion binding [P16406 ];
GO:0004177 (F) aminopeptidase activity [P16406 ];
GO:0006508 (P) proteolysis [P16406 ];
GO:0008237 (F) metallopeptidase activity [P16406 ];
GO:0001525 (P) angiogenesis [P16406 ];
GO:0016324 (C) apical plasma membrane [P16406 ];
GO:0031410 (C) cytoplasmic vesicle [P16406 ];
GO:0005903 (C) brush border [P16406 ];
GO:0005509 (F) calcium ion binding [P16406 ];
GO:0016021 (C) integral to membrane [P16406 ];

Subcellular localization

Localization

cell membrane [P16406 ];

Links

SwissProt

P16406

Entrez Gene

13809



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  Last Modified: 2009-03-24  
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