Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.2.1.3

Official Name

aconitate hydratase

Name from literature

aconitase

Pathway from literature

Pathway from KEGG

Energy Metabolism; Reductive carboxylate cycle (CO2 fixation); map00720

Carbohydrate Metabolism; Glyoxylate and dicarboxylate metabolism; map00630

Carbohydrate Metabolism; Citrate cycle (TCA cycle); map00020

Organisms

Rat (10116)

Genome localization

7q34[79250 ], 5q22[50655 ],

Comments

Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. An iron-sulfur protein, containing a [4Fe-4S] cluster to which the substrate binds.

Rate-limiting Description

"Mitochondria (m-)aconitase is a rate-limiting regulatory enzyme in prostate epithelial cells which minimizes citrate oxidation by these cells." (7589784)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q63270

phosphorylation;

Q9ER34

Gene ontology

Gene ontology

GO:0006099 (P) tricarboxylic acid cycle [Q63270, Q9ER34 ];
GO:0005739 (C) mitochondrion [Q9ER34 ];
GO:0051539 (F) 4 iron, 4 sulfur cluster binding [Q63270, Q9ER34 ];
GO:0005506 (F) iron ion binding [Q63270, Q9ER34 ];
GO:0003994 (F) aconitate hydratase activity [Q63270, Q9ER34 ];
GO:0005794 (C) Golgi apparatus [Q63270 ];

Subcellular localization

Localization

mitochondrion [Q9ER34 ];

cytoplasm [Q63270 ];

Links

SwissProt

Q63270; Q9ER34

Entrez Gene

50655; 79250



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  Last Modified: 2009-03-24  
  Design by Zhao Min