Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.8.2.2

Official Name

alcohol sulfotransferase

Name from literature

hydroxysteroid transferase

Pathway from literature

testosterone production

Pathway from KEGG

Lipid Metabolism; Androgen and estrogen metabolism; map00150

Energy Metabolism; Sulfur metabolism; map00920

Organisms

Rat (10116)

Genome localization

1q21.3-q22.1[24912 ], 1q21[24902 ], 1q21[361510 ],

Comments

Primary and secondary alcohols, including aliphatic alcohols, ascorbic acid, chloramphenicol, ephedrine and hydroxysteroids, but not phenolic steroids, can act as acceptors (cf. EC 2.8.2.15 steroid sulfotransferase).

Rate-limiting Description

"Reproductive toxicity: degenerative changes in the seminiferous epithelium, induction of the rate-limiting enzyme in testosterone production (3beta-hydroxysteroid transferase and 17 beta-hydroxysteroid transferase), histological changes in reproductive organs, testicular atrophy and the occurrence of ovarian cysts were noticed in rat." (7900959)

Gene ontology

Gene ontology

GO:0008202 (P) steroid metabolic process [P07631, P50235, Q29YR5, P22789 ];
GO:0005737 (C) cytoplasm [P07631, P50235, Q29YR5, P22789 ];
GO:0004027 (F) alcohol sulfotransferase activity [P07631, P50235, Q29YR5, P22789 ];

Subcellular localization

Localization

cytoplasm [P07631, P50235, Q29YR5, P22789 ];

Links

SwissProt

P07631; P22789; P50235; Q29YR5

Entrez Gene

24902; 24912; 361510



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  Last Modified: 2009-03-24  
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