Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.22

Official Name

2-acylglycerol O-acyltransferase

Name from literature

acyl coA : monoacylglycerol acyltransferase

Pathway from literature

re-synthesis of diacylglycerols in enterocytes

Pathway from KEGG

Lipid Metabolism; Glycerolipid metabolism; map00561

Organisms

Mouse (10090)

Comments

Various 2-acylglycerols can act as acceptor; palmitoyl-CoA and other long-chain acyl-CoAs can act as donors. The sn-1 position and the sn-3 position are both acylated, at about the same rate.

Rate-limiting Description

"Acyl-CoA:monoacylglycerol acyltransferase (MGAT) plays an important role in dietary fat absorption by catalyzing a rate-limiting step in the re-synthesis of diacylglycerols in enterocytes." (12730219)

Gene ontology

Gene ontology

GO:0005624 (C) membrane fraction [Q91ZV4 ];
GO:0006651 (P) diacylglycerol biosynthetic process [Q80W94, Q91ZV4 ];
GO:0019432 (P) triacylglycerol biosynthetic process [Q80W94 ];
GO:0016407 (F) acetyltransferase activity [Q80W94 ];
GO:0004144 (F) diacylglycerol O-acyltransferase activity [Q91ZV4 ];
GO:0050892 (P) intestinal absorption [Q80W94 ];
GO:0005789 (C) endoplasmic reticulum membrane [Q80W94, Q91ZV4 ];
GO:0006071 (P) glycerol metabolic process [Q80W94, Q91ZV4 ];
GO:0016021 (C) integral to membrane [Q80W94, Q91ZV4 ];
GO:0045454 (P) cell redox homeostasis [Q91ZV4 ];
GO:0003846 (F) 2-acylglycerol O-acyltransferase activity [Q80W94, Q91ZV4 ];

Subcellular localization

Localization

endoplasmic reticulum [Q80W94, Q91ZV4 ];

Links

SwissProt

Q80W94; Q91ZV4



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  Last Modified: 2009-03-24  
  Design by Zhao Min