Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.17.4.1

Official Name

ribonucleoside-diphosphate reductase

Name from literature

ribonucleotide reductase

Pathway from literature

deoxyribonucleotide synthesis

Pathway from KEGG

Metabolism of Other Amino Acids; Glutathione metabolism; map00480

Cellular Processes; Cell Growth and Death; p53 signaling pathway; map04115

Nucleotide Metabolism; Purine metabolism; map00230

Nucleotide Metabolism; Pyrimidine metabolism; map00240

Organisms

Yeast (4932)

Genome localization

-[856801 ], -[853091 ], -[854744 ], -[853427 ],

Comments

This enzyme is responsible for the de novo conversion of ribonucleoside diphosphates into deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair. An iron protein. While the enzyme is activated by ATP, it is inhibited by dATP [3,6].

Rate-limiting Description

"Ribonucleotide reductase (RNR) catalyzes the reduction of ribonucleotides to deoxyribonucleotides; this step is rate-limiting in DNA precursor synthesis." (10593972)

"Ribonucleotide reductase (RNR) catalyzes the rate-limiting step in de novo deoxyribonucleotide biosynthesis and is essential in DNA replication and repair." (16489218)

"Ribonucleotide reductase (RNR), comprising two large (R1) and two small (R2) subunits, catalyzes a rate-limiting step in the production of deoxyribonucleotides needed for DNA replication and repair." (16399800)

Regulatory Information

Upstream transcription factor

852582;855505

Regulatory type

Detail

phosphorylation;

P09938:from_uniprot:15_Phosphoserine

phosphorylation;

P09938:from_uniprot:22_Phosphoserine

phosphorylation;

P09938:from_uniprot:24_Phosphoserine

phosphorylation;

P09938:from_uniprot:374_Phosphoserine

phosphorylation;

P09938:from_uniprot:41_Phosphoserine

phosphorylation;

P09938:from_uniprot:7_Phosphoserine

phosphorylation;

P21524:from_uniprot:227_Phosphoserine

phosphorylation;

P21524:from_uniprot:809_Phosphoserine

phosphorylation;

P21524:from_uniprot:812_Phosphoserine

phosphorylation;

P21524:from_uniprot:816_Phosphoserine

phosphorylation;

P21524:from_uniprot:837_Phosphoserine

phosphorylation;

P21524:from_uniprot:887_Phosphoserine

phosphorylation;

P21672:from_uniprot:799_Phosphoserine

phosphorylation;

P21672:from_uniprot:806_Phosphoserine

phosphorylation;

P21672:from_uniprot:810_Phosphoserine

phosphorylation;

P21672:from_uniprot:866_Phosphoserine

phosphorylation;

P21672:from_uniprot:868_Phosphoserine

phosphorylation;

P49723:from_uniprot:169_Phosphoserine

phosphorylation;

P49723:from_uniprot:330_Phosphoserine

phosphorylation;

P49723:from_uniprot:332_Phosphoserine

phosphorylation;

P49723:from_uniprot:334_Phosphothreonine

phosphorylation;

P49723:from_uniprot:336_Phosphoserine

phosphorylation;

P49723:from_uniprot:55_Phosphoserine

phosphorylation;

P49723:from_uniprot:91_Phosphoserine

transcriptional factor;PAF1(852582)

"Phenotypic analysis of Paf1/RNA polymerase II complex mutations reveals connections to cell cycle regulation, protein synthesis, and lipid and nucleic acid metabolism." (12395202)

transcriptional factor;RAP1(855505)

"Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae." (7791768)

Gene ontology

Gene ontology

GO:0046914 (F) transition metal ion binding [P49723 ];
GO:0004748 (F) ribonucleoside-diphosphate reductase activity [P49723, P21524, P09938, P21672 ];
GO:0005739 (C) mitochondrion [P21672 ];
GO:0005506 (F) iron ion binding [P21524, P09938, P21672 ];
GO:0005524 (F) ATP binding [P21524, P21672 ];
GO:0009186 (P) deoxyribonucleoside diphosphate metabolic p... [P49723, P09938 ];
GO:0042802 (F) identical protein binding [P49723, P09938 ];
GO:0009263 (P) deoxyribonucleotide biosynthetic process [P49723, P21524, P09938, P21672 ];
GO:0005634 (C) nucleus [P49723, P09938 ];
GO:0005971 (C) ribonucleoside-diphosphate reductase complex [P49723, P21524, P09938, P21672 ];
GO:0006260 (P) DNA replication [P49723, P21524, P09938, P21672 ];
GO:0005515 (F) protein binding [P21524, P21672 ];
GO:0055114 (P) oxidation reduction [P49723, P21524, P09938, P21672 ];
GO:0051188 (P) cofactor biosynthetic process [P49723 ];

Subcellular localization

Localization

nucleus [P49723, P09938 ];

cytoplasm [P49723, P21524, P09938, P21672 ];

Links

SwissProt

P09938; P21524; P21672; P49723

Entrez Gene

853091; 853427; 854744; 856801



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min