Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.4.21.68

Official Name

t-plasminogen activator

Name from literature

tissue type plasminogen activator

Pathway from literature

the fibrinolytic cascade

Pathway from KEGG

Cellular Processes; Immune System; Complement and coagulation cascades; map04610

Organisms

Rat (10116)

Genome localization

16q12.5[25692 ],

Comments

A peptidase of family S1 (trypsin family) from a wide variety of mammalian tissues, especially endothelial cells. Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. Activity is considerably enhanced by fibrin. Formerly included in EC 3.4.21.31 and EC 3.4.99.26

Rate-limiting Description

"We investigated whether tissue plasminogen activator (tPA), a plasma serine protease that catalyzes the initial and rate-limiting step in fibrinolysis, inhibits postoperative intraperitoneal adhesion formation in rats." (9610055)

Gene ontology

Gene ontology

GO:0006508 (P) proteolysis [P19637 ];
GO:0004252 (F) serine-type endopeptidase activity [P19637 ];

Subcellular localization

Localization

extracellular [P19637 ];

Links

SwissProt

P19637

Entrez Gene

25692



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  Last Modified: 2009-03-24  
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