Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.1.1.17

Official Name

ornithine decarboxylase

Name from literature

ornithine decarboxylase

Pathway from literature

polyamine metabolism

Pathway from KEGG

Metabolism of Other Amino Acids; Glutathione metabolism; map00480

Amino Acid Metabolism; Urea cycle and metabolism of amino groups; map00220

Organisms

Mouse (10090)

Genome localization

12 A1.1|12 6.0 cM[18263 ],

Comments

A pyridoxal-phosphate protein.

Rate-limiting Description

"Ornithine decarboxylase (ODC) is the rate-limiting enzyme in the biosynthesis of polyamines, a family of cationic compounds required for optimal cell proliferation and differentiation." (11853879)

"We also found that the basal activity of ornithine decarboxylase (ODC), a rate-limiting enzyme of polyamine biosynthesis, was higher in Wobbler mice than in control animals." (9191978)

"Our results identify mammalian eIF4E as rate-limiting for cell cycle progression before it regulates cell growth." (14607835)

"We have examined the role in B cell activation of ornithine decarboxylase (ODC), the labile rate-limiting enzyme in the synthesis of polyamines thought to be required for S phase entry in all cells." (7865470)

"We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by alpha-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages." (9884080)

"The effects of 1alpha,25-(OH)2D3 were preceded by the suppression of ornithine decarboxylase (ODC) activity, a rate-limiting enzyme in polyamine metabolism." (9224728)

"Increased levels or overexpression of ornithine decarboxylase (ODC), a rate-limiting enzyme in polyamine biosynthesis pathway, is characteristic of tumor cells." (15228220)

"pMV7-4E cells (4E-P2), which overexpress translation initiation factor eIF-4E, contain elevated levels of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine biosynthesis." (8912847)

"Activity of ornithine decarboxylase (ODC), one of the rate-limiting enzymes in the pathway of polyamine biosynthesis, is regulated by various factors." (7874572)

"We have recently shown that administration of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine (PA) biosynthesis reduces pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice." (12856719)

"The first evidence that these molecules may be involved in such a process was based on the robust increase in the expression of the first and rate-limiting enzyme of biosynthesis of polyamines during immune stimuli." (12860970)

"We used transgenic mice to examine the effects of constitutive expression of ornithine decarboxylase (ODC), a key rate-limiting enzyme in polyamine biosynthesis, on histone acetylation in epithelial cells in skin." (11782361)

Regulatory Information

Upstream transcription factor

17869

Regulatory type

Detail

phosphorylation;

P00860

phosphorylation;

P00860:from_uniprot:303_Phosphoserine; by CK2

transcriptional factor;

"Here we report the studies of the expression of AR and c-Myc transcription factors involved in ODC transactivation. " (17520086)

transcriptional factor;Myc(17869)

"PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts." (15735755)

Gene ontology

Gene ontology

GO:0004586 (F) ornithine decarboxylase activity [P00860 ];
GO:0006596 (P) polyamine biosynthetic process [P00860 ];
GO:0001822 (P) kidney development [P00860 ];
GO:0008284 (P) positive regulation of cell proliferation [P00860 ];
GO:0005829 (C) cytosol [P00860 ];

Links

SwissProt

P00860

Entrez Gene

18263



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  Last Modified: 2009-03-24  
  Design by Zhao Min