Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.145/5.3.3.1

Official Name

steroid Delta-isomerase

Name from literature

beta hydroxysteroid dehydrogenase/isomerase

Pathway from literature

sex steroid production from pregnenolone

Pathway from KEGG

Lipid Metabolism; Androgen and estrogen metabolism; map00150

Lipid Metabolism; C21-Steroid hormone metabolism; map00140

Organisms

Rat (10116)

Genome localization

2q34[24470 ], 2q34[29632 ],

Comments

May be at least three distinct enzymes.

Rate-limiting Description

"The rate-limiting step in steroidogenesis is the transfer of cholesterol to the inner mitochondrial membrane." (9065457)

"Therefore, we would propose that the major effect of chronic ethanol ingestion upon the enzymes required for testosterogenesis is the reduction of 3 beta-hydroxysteroid dehydrogenase/isomerase activity, the rate limiting step in sex steroid production from pregnenolone.." (7018303)

Regulatory Information

Upstream transcription factor

313929;54244;83516

Regulatory type

Detail

transcriptional factor;"PGC-1alpha(83516),CBP(54244)/SRC-1(313929)"

"ERalpha interaction with transcription coregulators, histone acetylases (CBP/SRC-1), and PGC-1alpha is crucial to FSH and TGFbeta1-up-regulated expression of Hsd3b and Cyp11a1, and, thus, progesterone production in rat ovarian granulosa cells." (18511507)

transcriptional factor;"CBP/SRC-1,PGC-1alpha(83516)"

"ERalpha interaction with transcription coregulators, histone acetylases (CBP/SRC-1), and PGC-1alpha is crucial to FSH and TGFbeta1-up-regulated expression of Hsd3b and Cyp11a1, and, thus, progesterone production in rat ovarian granulosa cells." (18511507)

Gene ontology

Gene ontology

GO:0031966 (C) mitochondrial membrane [P22072, P22071, Q62878 ];
GO:0003854 (F) 3-beta-hydroxy-delta5-steroid dehydrogenase... [P22072, P22071, Q62878 ];
GO:0016021 (C) integral to membrane [P22072, P22071, Q62878 ];
GO:0006700 (P) C21-steroid hormone biosynthetic process [P22072, P22071, Q62878 ];
GO:0005488 (F) binding [P22072, P22071, Q62878 ];
GO:0055114 (P) oxidation reduction [P22072, P22071, Q62878 ];
GO:0005789 (C) endoplasmic reticulum membrane [P22072, P22071, Q62878 ];
GO:0004769 (F) steroid delta-isomerase activity [P22072, P22071, Q62878 ];

Subcellular localization

Localization

mitochondrion [P22072, P22071, Q62878 ];

endoplasmic reticulum [P22072, P22071, Q62878 ];

Links

SwissProt

P22071; P22072; Q62878

Entrez Gene

24470; 29632; 24470; 29632



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  Last Modified: 2009-03-24  
  Design by Zhao Min