Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.145/5.3.3.1

Official Name

steroid Delta-isomerase

Name from literature

beta hydroxysteroid dehydrogenase/isomerase

Pathway from literature

sex steroid production from pregnenolone

Pathway from KEGG

Lipid Metabolism; Androgen and estrogen metabolism; map00150

Lipid Metabolism; C21-Steroid hormone metabolism; map00140

Organisms

Mouse (10090)

Genome localization

3 F2.2[15497 ], 3 F2.2|3 49.1 cM[15492 ], 3 F2.2|3 49.1 cM[15495 ], 3 F2.2[15496 ], 3 F2.2|3 49.1 cM[15493 ],

Comments

May be at least three distinct enzymes.

Rate-limiting Description

"The rate-limiting step in steroidogenesis is the transfer of cholesterol to the inner mitochondrial membrane." (9065457)

Regulatory Information

Regulatory type

Detail

others;

"The steroid hormone enzyme 3beta-hydroxysteroid dehydrogenase 4 (3betaHSD4) was identified as a novel target of vasopressin regulation. Its expression is colocalized in AQP2-expressing collecting ducts of the kidney." (16478974)

Gene ontology

Gene ontology

GO:0031966 (C) mitochondrial membrane [P24815, O35469, P26149 ];
GO:0006700 (P) C21-steroid hormone biosynthetic process [P26150, P24815, O35469, P26149 ];
GO:0005789 (C) endoplasmic reticulum membrane [P26150, P24815, O35469, P26149 ];
GO:0004769 (F) steroid delta-isomerase activity [P26150, P24815, O35469, P26149 ];
GO:0003854 (F) 3-beta-hydroxy-delta5-steroid dehydrogenase... [P26150, P24815, O35469, P26149 ];
GO:0016021 (C) integral to membrane [P26150, P24815, O35469, P26149 ];
GO:0005488 (F) binding [P26150, P24815, O35469, P26149 ];
GO:0055114 (P) oxidation reduction [P26150, P24815, O35469, P26149 ];
GO:0005743 (C) mitochondrial inner membrane [P26150 ];

Subcellular localization

Localization

mitochondrion [P26150, P24815, O35469, P26149 ];

endoplasmic reticulum [P26150, P24815, O35469, P26149 ];

Links

SwissProt

O35469; P24815; P26149; P26150

Entrez Gene

15492; 15493; 15495; 15496; 15497; 15492; 15493; 15497



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min