Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.4.2.7

Official Name

adenine phosphoribosyltransferase

Name from literature

adenine phosphoribosyl transferase

Pathway from literature

AMP formation and subsequently the formation of ADP and ATP

Pathway from KEGG

Nucleotide Metabolism; Purine metabolism; map00230

Organisms

Mouse (10090)

Genome localization

8 E1|8 67.0 cM[11821 ],

Comments

5-Amino-4-imidazolecarboxamide can replace adenine.

Rate-limiting Description

"The reciprocal plots for 5-phosphoribosyl-1-pyrophosphate (PRPP) of liver and hepatoma enzymes gave apparent KmS of 2 microM for adenine phosphoribosyltransferase and 4 microM for HGPRT, showing two orders of magnitude higher affinities for PRPP than that of the rate-limiting enzyme of de novo purine synthesis, amidophosphoribosyltransferase (EC 2.4.2.14) (Km = 400 to 900 microM)." (6327016)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P08030

epigenetic;

"The primary function of a redundant Sp1 binding site in the mouse aprt gene promoter is to block epigenetic gene inactivation." (9801314#7958895)

Gene ontology

Gene ontology

GO:0006166 (P) purine ribonucleoside salvage [P08030 ];
GO:0003999 (F) adenine phosphoribosyltransferase activity [P08030 ];
GO:0006168 (P) adenine salvage [P08030 ];
GO:0007625 (P) grooming behavior [P08030 ];
GO:0005737 (C) cytoplasm [P08030 ];
GO:0002055 (F) adenine binding [P08030 ];

Subcellular localization

Localization

cytoplasm [P08030 ];

Links

SwissProt

P08030

Entrez Gene

11821



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  Last Modified: 2009-03-24  
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