Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.4.23.15

Official Name

renin

Name from literature

Renin

Pathway from literature

renin-angiotensin system

Pathway from KEGG

Cellular Processes; Endocrine System; Renin - angiotensin system; map04614

Organisms

Rat (10116)

Genome localization

13q13[24715 ],

Comments

Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family).

Rate-limiting Description

"Renin is the rate-limiting step in angiotensin II production." (10766031)

Regulatory Information

Upstream transcription factor

24356;303991

Regulatory type

Detail

transcriptional factor;"Ets-1(24356),HOXD10(303991),PBX1b,PREP1"

"show that the intracellular domain of Notch1, transcription factor Ets-1, and homeo box D10 (HOXD10).pre B-cell leukemia transcription factor 1(PBX1b).PREP1 activate the rat renin promoter cooperatively" (15792957)

Gene ontology

Gene ontology

GO:0016020 (C) membrane [P08424 ];
GO:0004190 (F) aspartic-type endopeptidase activity [P08424 ];

Subcellular localization

Localization

extracellular [P08424 ];

membrane [P08424 ];

Links

SwissProt

P08424

Entrez Gene

24715



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min