Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.4.23.15

Official Name

renin

Name from literature

Renin

Pathway from literature

renin-angiotensin system

Pathway from KEGG

Cellular Processes; Endocrine System; Renin - angiotensin system; map04614

Organisms

Mouse (10090)

Genome localization

1 E4|1 69.9 cM[19702 ], 1 E4|1 69.9 cM[19701 ],

Comments

Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family).

Rate-limiting Description

"Renin, as the rate-limiting enzyme in the synthesis of the potent vasoactive peptide angiotensin II, has been studied for more than 100 years." (10868475)

"Renin release from juxtaglomerular granular cells is considered the rate-limiting step in activation of the renin-angiotensin system that helps to maintain body salt and water balance." (15082450)

Regulatory Information

Upstream transcription factor

21405;20687;20683

Regulatory type

Detail

transcriptional level;TNF-alpha(21926)

"renin transcription is regulated by TNFalpha, which is regulatedby NFkappaB" (14563845)

transcriptional level;TNF-alpha(21926)

"TNFalpha inhibits renin gene expression by decreasing the transactivating capacity of NFkappaB-p65 and partially by attenuating CREB1 binding to CRE" (15857826)

transcriptional factor;Sp3(20687),Sp1(20683),Hnf1(21405)

"Regulation of renin enhancer activity by nuclear factor I and Sp1/Sp3." (12591615)

Gene ontology

Gene ontology

GO:0048469 (P) cell maturation [P06281 ];
GO:0002003 (P) angiotensin maturation [P06281 ];
GO:0016020 (C) membrane [P06281 ];
GO:0005615 (C) extracellular space [P06281 ];
GO:0006508 (P) proteolysis [P00796 ];
GO:0004190 (F) aspartic-type endopeptidase activity [P00796, P06281 ];
GO:0042756 (P) drinking behavior [P06281 ];
GO:0005576 (C) extracellular region [P00796 ];
GO:0009755 (P) hormone-mediated signaling [P06281 ];
GO:0002016 (P) regulation of blood volume by renin-angiote... [P06281 ];

Subcellular localization

Localization

extracellular [P00796, P06281 ];

membrane [P06281 ];

Links

SwissProt

P00796; P06281

Entrez Gene

19701; 19702



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  Last Modified: 2009-03-24  
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