Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.1.3.5

Official Name

5'-nucleotidase

Name from literature

5'-nucleotidase

Pathway from literature

transformation of AMP to adenosine

Pathway from KEGG

Metabolism of Cofactors and Vitamins; Nicotinate and nicotinamide metabolism; map00760

Nucleotide Metabolism; Purine metabolism; map00230

Nucleotide Metabolism; Pyrimidine metabolism; map00240

Organisms

Rat (10116)

Genome localization

4q24[312373 ], 10q22[287368 ], 8q31[58813 ], 5q36[313574 ],

Comments

Wide specificity for 5'-nucleotides.

Rate-limiting Description

"In H9c2 cells, in which 5'-nucleotidase activity was rate-limiting, only cN-II overexpression accelerated inosine and hypoxanthine formation." (10766785)

"AMP, ADP, and ATP were all rapidly converted to adenosine, with a T1/2 for ATP conversion to adenosine of approximately 200 msec, and the last step in this pathway (transformation of AMP to adenosine by 5'-nucleotidase) seems to be the rate-limiting step." (9315889)

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [Q6AYP7 ];
GO:0008270 (F) zinc ion binding [P21588 ];
GO:0008253 (F) 5'-nucleotidase activity [P21588, Q6AYP7 ];
GO:0031225 (C) anchored to membrane [P21588 ];
GO:0000166 (F) nucleotide binding [P21588, Q6AYP7 ];
GO:0005886 (C) plasma membrane [P21588 ];
GO:0005737 (C) cytoplasm [Q6AYP7 ];
GO:0009166 (P) nucleotide catabolic process [P21588 ];
GO:0009117 (P) nucleotide metabolic process [Q6AYP7 ];
GO:0016740 (F) transferase activity [Q6AYP7 ];

Subcellular localization

Localization

cell membrane [P21588 ];

cytoplasm [Q6AYP7 ];

Links

SwissProt

P21588; Q6AYP7

Entrez Gene

287368; 312373; 313574; 58813



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  Last Modified: 2009-03-24  
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