Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.1

Official Name

hexokinase

Name from literature

hexokinase

Pathway from literature

glycolysis

Pathway from KEGG

Carbohydrate Metabolism; Starch and sucrose metabolism; map00500

Carbohydrate Metabolism; Aminosugars metabolism; map00530

Carbohydrate Metabolism; Fructose and mannose metabolism; map00051

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Carbohydrate Metabolism; Galactose metabolism; map00052

Biosynthesis of Secondary Metabolites; Streptomycin biosynthesis; map00521

Organisms

Rat (10116)

Genome localization

17q12[25060 ], 4q34[25059 ], 20q11[25058 ],

Comments

D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.

Rate-limiting Description

"The major rate-limiting step for glycolysis was the transport of glucose across the blood-brain barrier into the brain." (16046853)

"The first rate-limiting enzymes in intracellular glucose metabolism are the hexokinases, which catalyze the phosphorylation of glucose." (12660493)

"In conclusion, the insulin-induced changes in the tracer-to-tracee ratio are due to a shift of the rate-limiting step for glucose uptake from transport to phosphorylation by hexokinase." (9755073)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P27881

phosphorylation;

P27926

phosphorylation;

P05708:from_uniprot:27_Phosphotyrosine

phosphorylation;

P27881:from_uniprot:461_Phosphotyrosine

Gene ontology

Gene ontology

GO:0004396 (F) hexokinase activity [P27881, P27926, P05708 ];
GO:0006096 (P) glycolysis [P27881, P27926, P05708 ];
GO:0005741 (C) mitochondrial outer membrane [P05708 ];
GO:0005524 (F) ATP binding [P27881, P27926, P05708 ];

Subcellular localization

Localization

mitochondrion [P05708 ];

Links

SwissProt

P05708; P27881; P27926

Entrez Gene

25058; 25059; 25060



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  Last Modified: 2009-03-24  
  Design by Zhao Min