Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.68

Official Name

1-phosphatidylinositol-4-phosphate 5-kinase

Name from literature

phosphatidylinositol phosphate kinase

Pathway from literature

PA biosynthesis

Pathway from KEGG

Cellular Processes; Cell Motility; Regulation of actin cytoskeleton; map04810

Environmental Information Processing; Signal Transduction; Phosphatidylinositol signaling system; map04070

Carbohydrate Metabolism; Inositol phosphate metabolism; map00562

Organisms

Rat (10116)

Genome localization

7q11[314641 ], 7q22[140607 ], 10q31[89812 ], 17q12.3[116723 ], 9q32[316457 ], 1q51[309419 ],

Comments

This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known.

Rate-limiting Description

"As phosphatidylinositol 4-kinase is the rate-limiting enzyme for the production of phosphatidylinositol 4,5-bisphosphate, which is the preferred substrate for phospholipase C, we investigated the expression of phosphatidylinositol 4-kinase messenger RNA." (8190262)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q5I6B8:from_uniprot:671_Phosphotyrosine; by CSK

phosphorylation;

"Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles" (15546921)

Gene ontology

Gene ontology

GO:0016020 (C) membrane [Q5CZZ9 ];
GO:0012505 (C) endomembrane system [Q5CZZ9 ];
GO:0046488 (P) phosphatidylinositol metabolic process [Q5I6B8, Q5CZZ9 ];
GO:0005886 (C) plasma membrane [Q5I6B8 ];
GO:0016308 (F) 1-phosphatidylinositol-4-phosphate 5-kinase... [Q5I6B8, Q5CZZ9 ];

Subcellular localization

Localization

cell membrane [Q5I6B8 ];

membrane [Q5CZZ9 ];

cytoplasm [Q5I6B8 ];

Links

SwissProt

Q5CZZ9; Q5I6B8

Entrez Gene

116723; 140607; 309419; 314641; 316457; 89812



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  Last Modified: 2009-03-24  
  Design by Zhao Min