Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.4.19.6

Official Name

pyroglutamyl-peptidase II

Name from literature

pyroglutamyl aminopeptidase I

Pathway from literature

Organisms

Rat (10116)

Genome localization

7q22[366894 ],

Comments

Highly specific for thyrotropin releasing hormone (pyroglutamyl-histidyl-prolylamide). Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone releasing hormone. Found in serum and brain. Inhibited by metal chelators. In peptidase family M1 (membrane alanyl aminopeptidase family)

Rate-limiting Description

"This tripeptide, a potential prodrug of L-Dopa, is absorbed by the intestinal peptide transporter, is relatively stable in the gut wall, and is converted to L-Dopa by peptidases with the cleavage by pyroglutamyl aminopeptidase I to L-Dopa-Pro as the rate limiting step." (7494810)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q10836:from_uniprot:30_Phosphothreonine; by PKC

Gene ontology

Gene ontology

GO:0008270 (F) zinc ion binding [Q10836 ];
GO:0004177 (F) aminopeptidase activity [Q10836 ];
GO:0016021 (C) integral to membrane [Q10836 ];
GO:0006508 (P) proteolysis [Q10836 ];
GO:0008237 (F) metallopeptidase activity [Q10836 ];

Subcellular localization

Localization

cell membrane [Q10836 ];

Links

SwissProt

Q10836

Entrez Gene

366894



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  Last Modified: 2009-03-24  
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