Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.3.8

Official Name

ATP citrate synthase

Name from literature

citrate lyase

Pathway from literature

de novo synthesis of fatty acids and triglycerides

Pathway from KEGG

Energy Metabolism; Reductive carboxylate cycle (CO2 fixation); map00720

Carbohydrate Metabolism; Citrate cycle (TCA cycle); map00020

Organisms

Rat (10116)

Genome localization

10q32.1[24159 ],

Comments

The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate---CoA ligase).

Rate-limiting Description

"The effect of thyroparathyroidectomy (TPTX) on ATP citrate lyase regulation, a rate-limiting enzyme of fatty acid synthesis in hepatic cytosol, was investigated in rats refed after a 24 h fast." (3108130)

Regulatory Information

Upstream transcription factor

24790;78968

Regulatory type

Detail

phosphorylation;

P16638:from_uniprot:1099_Phosphoserine

phosphorylation;

P16638:from_uniprot:131_Phosphotyrosine

phosphorylation;

P16638:from_uniprot:446_Phosphothreonine

phosphorylation;

P16638:from_uniprot:450_Phosphoserine

phosphorylation;

P16638:from_uniprot:454_Phosphoserine; by PKA

phosphorylation;

P16638:from_uniprot:480_Phosphoserine

phosphorylation;

P16638:from_uniprot:681_Phosphotyrosine

transcriptional factor;Sp1(24790)

"Results suggest that Sp1 acts on the ATP citrate lyase promoter to produce basal and induced transcription by low fat/high carbohydrate diets." (11989980)

transcriptional factor;SREBP1a(78968)

"Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins." (10777536)

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [P16638 ];
GO:0044262 (P) cellular carbohydrate metabolic process [P16638 ];
GO:0008610 (P) lipid biosynthetic process [P16638 ];
GO:0004775 (F) succinate-CoA ligase (ADP-forming) activity [P16638 ];
GO:0005737 (C) cytoplasm [P16638 ];
GO:0003878 (F) ATP citrate synthase activity [P16638 ];
GO:0005524 (F) ATP binding [P16638 ];

Subcellular localization

Localization

cytoplasm [P16638 ];

Links

SwissProt

P16638

Entrez Gene

24159



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  Last Modified: 2009-03-24  
  Design by Zhao Min