Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.2.3.12

Official Name

6-pyruvoyltetrahydropterin synthase

Name from literature

pyruvoyl tetrahydropterin synthase

Pathway from literature

synthesizing BH4/the synthesis of human tetrahydrobiopterin

Pathway from KEGG

Metabolism of Cofactors and Vitamins; Folate biosynthesis; map00790

Organisms

Mouse (10090)

Genome localization

9 A5.3[19286 ],

Comments

Catalyses triphosphate elimination and an intramolecular redox reaction in the presence of Mg2+. It has been identified in human liver. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 (sepiapterin reductase) and EC 3.5.4.16 (GTP cyclohydrolase I) [3].

Rate-limiting Description

"Enzymes involved in its synthesis are the rate limiting enzyme GTP cyclohydrolase I, 6-pyruvoyl tetrahydropterin synthase (PTPS) and sepiapterin reductase." (11778454)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q9R1Z7

phosphorylation;

Q9R1Z7:from_uniprot:18_Phosphoserine

Gene ontology

Gene ontology

GO:0008270 (F) zinc ion binding [Q9R1Z7 ];
GO:0006729 (P) tetrahydrobiopterin biosynthetic process [Q9R1Z7 ];
GO:0042803 (F) protein homodimerization activity [Q9R1Z7 ];
GO:0003874 (F) 6-pyruvoyltetrahydropterin synthase activity [Q9R1Z7 ];

Links

SwissProt

Q9R1Z7

Entrez Gene

19286



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  Last Modified: 2009-03-24  
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