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| Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
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Basic Information |
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Enzyme Number | 4.2.3.12 |
Official Name | 6-pyruvoyltetrahydropterin synthase |
Name from literature | pyruvoyl tetrahydropterin synthase |
Pathway from literature | synthesizing BH4/the synthesis of human tetrahydrobiopterin |
Pathway from KEGG |
Metabolism of Cofactors and Vitamins; Folate biosynthesis; map00790 |
Organisms | Mouse (10090) |
Genome localization | 9 A5.3[19286 ], |
Comments | Catalyses triphosphate elimination and an intramolecular redox reaction in the presence of Mg2+. It has been identified in human liver. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 (sepiapterin reductase) and EC 3.5.4.16 (GTP cyclohydrolase I) [3]. |
Rate-limiting Description | "Enzymes involved in its synthesis are the rate limiting enzyme GTP cyclohydrolase I, 6-pyruvoyl tetrahydropterin synthase (PTPS) and sepiapterin reductase." (11778454) |
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Regulatory Information |
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Regulatory type | Detail |
phosphorylation; | Q9R1Z7 |
phosphorylation; | Q9R1Z7:from_uniprot:18_Phosphoserine |
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Gene ontology |
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Gene ontology |
GO:0008270 (F) zinc ion binding [Q9R1Z7 ]; |
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Links |
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SwissProt | |
Entrez Gene |