Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.13.11.52

Official Name

indoleamine 2,3-dioxygenase

Name from literature

Indoleamine 2,3-dioxygenase

Pathway from literature

the kynurenine pathway of tryptophan metabolism/UV filter biosynthesis

Pathway from KEGG

Amino Acid Metabolism; Tryptophan metabolism; map00380

Organisms

Mouse (10090)

Genome localization

8 A2[209176 ], 8 A2[15930 ],

Comments

A protohemoprotein. Requires ascorbic acid and methylene blue for activity. This enzyme has broader substrate specificity than EC 1.13.11.11, tryptophan 2,3-dioxygenase [1]. It is induced in response to pathological conditions and host-defense mechanisms and its distribution in mammals is not confined to the liver [2]. While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan [2,6]. Superoxide radicals can replace O2 as oxygen donor [4,7].

Rate-limiting Description

"Indoleamine 2,3-dioxygenase (IDO), a rate-limiting enzyme in the tryptophan catabolism, has been shown to play an important role in various forms of immune tolerance." (17055065)

Gene ontology

Gene ontology

GO:0020037 (F) heme binding [P28776 ];
GO:0005737 (C) cytoplasm [P28776 ];
GO:0005506 (F) iron ion binding [P28776 ];
GO:0006952 (P) defense response [P28776 ];
GO:0019441 (P) tryptophan catabolic process to kynurenine [P28776 ];
GO:0055114 (P) oxidation reduction [P28776 ];
GO:0004833 (F) tryptophan 2, 3-dioxygenase activity [P28776 ];
GO:0033754 (F) indoleamine 2, 3-dioxygenase activity [P28776 ];

Links

SwissProt

P28776

Entrez Gene

15930; 209176



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  Last Modified: 2009-03-24  
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