Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.85

Official Name

fatty-acid synthase

Name from literature

fatty acid synthase

Pathway from literature

fatty acid biosynthetic pathway

Pathway from KEGG

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Lipid Metabolism; Fatty acid biosynthesis; map00061

Organisms

Mouse (10090)

Genome localization

11 E2|11 72.0 cM[14104 ],

Comments

The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 3-oxoacyl-[acyl-carrier-protein] synthase, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.61 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase.

Rate-limiting Description

"As a physiologic consequence of AMPK activation, acetyl-CoA carboxylase (ACC), the rate-limiting enzyme of fatty acid synthesis, was phosphorylated and inhibited whereas glucose oxidation was increased." (17409402)

"Pharmacological inhibition of fatty acid synthase (FAS), rate limiting for de novo lipogenesis, decreases appetite independently of leptin but also promotes weight loss through activities unrelated to FAS inhibition." (17694178)

"Fatty acid synthase and steaoryl-coenzyme A desaturase, the two rate-limiting enzymes in lipogenesis, were upregulated in neoplastic relative to dysplastic livers." (18285497)

Regulatory Information

Upstream transcription factor

22259;20787;19013

Regulatory type

Detail

phosphorylation;

P19096

phosphorylation;

P19096:from_uniprot:207_Phosphoserine

phosphorylation;

P19096:from_uniprot:2229_Phosphoserine

transcriptional factor;SREBP(20787)

"fatty acid synthase gene is regulated by SREBP" (12897158)

transcriptional factor;"PPARalpha(19013),LXRalpha(22259)"

"PPARalpha is required to mediate the response of Scd-1 and Fas gene expression to insulin and that this is normally achieved directly by activation of LXRalpha." (18079124)

phosphorylation;

"AMP-activated protein kinase-induced Fatty acid synthase phosphorylation inhibits lipogenesis." (17635921)

Gene ontology

Gene ontology

GO:0048037 (F) cofactor binding [P19096 ];
GO:0008270 (F) zinc ion binding [P19096 ];
GO:0016491 (F) oxidoreductase activity [O89060 ];
GO:0004319 (F) enoyl- [acyl-carrier-protein] reductase (NAD... [P19096 ];
GO:0004315 (F) 3-oxoacyl- [acyl-carrier-protein] synthase a... [P19096 ];
GO:0004317 (F) 3-hydroxypalmitoyl- [acyl-carrier-protein] d... [P19096 ];
GO:0005488 (F) binding [O89060 ];
GO:0042470 (C) melanosome [P19096 ];
GO:0004316 (F) 3-oxoacyl- [acyl-carrier-protein] reductase ... [P19096 ];
GO:0031177 (F) phosphopantetheine binding [P19096 ];
GO:0004313 (F) [acyl-carrier-protein] S-acetyltransferase ... [P19096 ];
GO:0000036 (F) acyl carrier activity [P19096 ];
GO:0006633 (P) fatty acid biosynthetic process [P19096 ];
GO:0004320 (F) oleoyl- [acyl-carrier-protein] hydrolase act... [P19096 ];
GO:0004312 (F) fatty-acid synthase activity [O89060 ];
GO:0004314 (F) [acyl-carrier-protein] S-malonyltransferase... [P19096 ];
GO:0009058 (P) biosynthetic process [O89060 ];
GO:0055114 (P) oxidation reduction [P19096 ];
GO:0042587 (C) glycogen granule [P19096 ];

Subcellular localization

Localization

cytoplasm [P19096 ];

Links

SwissProt

O89060; P19096

Entrez Gene

14104



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  Last Modified: 2009-03-24  
  Design by Zhao Min