Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.2.1.11

Official Name

phosphopyruvate hydratase

Name from literature

enolase

Pathway from literature

glycolytic pathway

Pathway from KEGG

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Organisms

Rat (10116)

Genome localization

10q24[25438 ], 4q42[24334 ], 5q36[24333 ],

Comments

Also acts on 3-phospho-D-erythronate.

Rate-limiting Description

"A protein with a molecular mass of 52 kDa that is strongly induced by ERK1/2 activation in response to ischemic hypoxia and reoxygenation was identified as alpha-enolase, a rate-limiting enzyme in the glycolytic pathway, by liquid chromatography-mass spectrometry and amino acid sequencing." (15459207)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P04764:from_uniprot:263_Phosphoserine

phosphorylation;

P04764:from_uniprot:287_Phosphotyrosine

phosphorylation;

P04764:from_uniprot:44_Phosphotyrosine

phosphorylation;

P04764:from_uniprot:63_Phosphoserine

phosphorylation;

P04764:from_uniprot:72_Phosphothreonine

phosphorylation;

P07323:from_uniprot:44_Phosphotyrosine

phosphorylation;

P07323:from_uniprot:80_Phosphoserine

phosphorylation;

"The alpha-enolase hyper-phosphorylation in hypertrophied left ventricle was accompanied by decreased enzymatic activity." (18468517)

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [P15429, P04764, P07323 ];
GO:0004634 (F) phosphopyruvate hydratase activity [P15429, P04764, Q5EB49, Q5BJ93, P07323 ];
GO:0006096 (P) glycolysis [P15429, P04764, Q5EB49, Q5BJ93, P07323 ];
GO:0005886 (C) plasma membrane [P04764, P07323 ];
GO:0000015 (C) phosphopyruvate hydratase complex [P15429, P04764, P07323 ];
GO:0004252 (F) serine-type endopeptidase activity [P04764 ];

Subcellular localization

Localization

cell membrane [P04764, P07323 ];

myofibril [P15429 ];

cytoplasm [P15429, P04764, P07323 ];

Links

SwissProt

P04764; P07323; P15429; Q5BJ93; Q5EB49

Entrez Gene

24333; 24334; 25438



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min