Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.57

Official Name

diamine N-acetyltransferase

Name from literature

spermidine/spermine N-acetyltransferase

Pathway from literature

the polyamine catabolic pathway

Pathway from KEGG

Amino Acid Metabolism; Urea cycle and metabolism of amino groups; map00220

Organisms

Mouse (10090)

Genome localization

11 B4[69215 ], X F3-F4|X 65.2 cM[20229 ],

Comments

Acts on propane-1,3-diamine, pentane-1,5-diamine, putrescine, spermidine (forming N1- and N8-acetylspermidine), spermine, N1-acetylspermidine and N8-acetylspermidine.

Rate-limiting Description

"Overexpression of the rate-limiting enzyme in polyamine catabolism spermidine/spermine N1-acetyltransferase (SSAT) in transgenic (Tg) mouse leads to accumulation of putrescine in the skin and permanent hair loss at the age of 3 wk." (15737201)

Gene ontology

Gene ontology

GO:0004145 (F) diamine N-acetyltransferase activity [P48026, Q6P8J2 ];
GO:0046208 (P) spermine catabolic process [P48026 ];
GO:0005737 (C) cytoplasm [P48026 ];
GO:0008152 (P) metabolic process [Q6P8J2 ];

Subcellular localization

Localization

cytoplasm [P48026 ];

Links

SwissProt

P48026; Q6P8J2

Entrez Gene

20229; 69215



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  Last Modified: 2009-03-24  
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