Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.1.1.22

Official Name

histidine decarboxylase

Name from literature

histidine decarboxylase

Pathway from literature

histamine synthesis

Pathway from KEGG

Amino Acid Metabolism; Histidine metabolism; map00340

Organisms

Mouse (10090)

Genome localization

2 E5-G[15186 ],

Comments

A pyridoxal-phosphate protein (in animal tissues). The bacterial enzyme has a pyruvoyl residue as prosthetic group.

Rate-limiting Description

"Histidine decarboxylase (HDC) is the rate-limiting enzyme for histamine production." (10843737)

"Based on this analogy, we investigated the expression of histidine decarboxylase (HDC), the rate-limiting enzyme of histamine synthesis, in mouse male germ cells." (11827977)

"Infiltrating polymorphonuclear leukocytes (PMN) in the peritoneal cavity were found to express L-histidine decarboxylase (HDC), the rate-limiting enzyme of histamine synthesis, in a csein-induced peritonitis model." (15114681)

"We have studied histidine decarboxylase (HDC), the rate-limiting enzyme for mammalian histamine synthesis." (12875237)

Regulatory Information

Upstream transcription factor

20683

Regulatory type

Detail

transcriptional factor;Sp1(20683)

"Sp1 is one of the transcription factors that regulate the LPS-induced expression of HDC in RAW 264 cells" (16949047)

Gene ontology

Gene ontology

GO:0030170 (F) pyridoxal phosphate binding [P23738 ];
GO:0004398 (F) histidine decarboxylase activity [P23738 ];
GO:0042423 (P) catecholamine biosynthetic process [P23738 ];
GO:0006548 (P) histidine catabolic process [P23738 ];

Links

SwissProt

P23738

Entrez Gene

15186



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  Last Modified: 2009-03-24  
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