Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.3.1.2

Official Name

dihydropyrimidine dehydrogenase (NADP+)

Name from literature

dihydropyrimidine dehydrogenase

Pathway from literature

5-fluorouracil (5-FU) chemotherapy catabolic pathway

Pathway from KEGG

Metabolism of Other Amino Acids; beta-Alanine metabolism; map00410

Xenobiotics Biodegradation and Metabolism; Drug metabolism - other enzymes; map00983

Nucleotide Metabolism; Pyrimidine metabolism; map00240

Organisms

Mouse (10090)

Genome localization

3 G1[99586 ],

Comments

Also acts on dihydrothymine.

Rate-limiting Description

"The administered 5-FU is degraded mainly in the liver by dihydropyrimidine dehydrogenase (DPD), which is the initial rate-limiting enzyme in the catabolic pathway of pyrimidine." (12527935)

"BACKGROUND & OBJECTIVE: Anti-cancer effect of 5-Fluorouracil (5-FU) is mediated mainly by inhibition of the thymidylate synthase (TS), while dihydropyrimidine dehydrogenase (DPD) is an initial and a rate-limiting catabolic enzyme of 5-FU." (15025949)

"Protein levels and gene expression of dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme for degradation of 5-fluorouracil, were studied in two human tumor cell lines (fibrosarcoma HT-1080 and pancreatic carcinoma MIAPaCa-2) in various growth phases of the cultured cells and of tumor xenografts implanted into nude mice." (9914783)

"Interspecies differences in dihydropyrimidine dehydrogenase (DPD), the initial and rate-limiting enzyme in pyrimidine degradation, were assessed in cytosol from livers isolated from human, monkey, dog, rat, and mouse." (9597696)

"The circadian-dependent efficacy and toxicity of 5-FU are related to the circadian variation in the activity of dihydropyrimidine dehydrogenase (DPD), which is a rate-limiting enzyme in the pyrimidine catabolic pathway." (11376565)

"BACKGROUND: Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in catabolism of pyrimidines including 5-fluorouracil." (12104082)

"Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme of 5-fluorouracil (FU) catabolism." (12651209)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q8CHR6

phosphorylation;

Q8CHR6:from_uniprot:577_Phosphoserine

Gene ontology

Gene ontology

GO:0006207 (P) 'de novo' pyrimidine base biosynthetic process [Q8CHR6 ];
GO:0051539 (F) 4 iron, 4 sulfur cluster binding [Q8CHR6 ];
GO:0005829 (C) cytosol [Q8CHR6 ];
GO:0005506 (F) iron ion binding [Q8CHR6 ];
GO:0017113 (F) dihydropyrimidine dehydrogenase (NADP+) act... [Q8CHR6 ];
GO:0004158 (F) dihydroorotate oxidase activity [Q8CHR6 ];
GO:0009055 (F) electron carrier activity [Q8CHR6 ];
GO:0006212 (P) uracil catabolic process [Q8CHR6 ];
GO:0006214 (P) thymidine catabolic process [Q8CHR6 ];
GO:0055114 (P) oxidation reduction [Q8CHR6 ];

Subcellular localization

Localization

cytoplasm [Q8CHR6 ];

Links

SwissProt

Q8CHR6

Entrez Gene

99586



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  Last Modified: 2009-03-24  
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