Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.1.1.28

Official Name

aromatic-L-amino-acid decarboxylase

Name from literature

aromatic amino acid decarboxylase

Pathway from literature

renal dopamine formation

Pathway from KEGG

Amino Acid Metabolism; Tryptophan metabolism; map00380

Amino Acid Metabolism; Histidine metabolism; map00340

Amino Acid Metabolism; Phenylalanine metabolism; map00360

Biosynthesis of Secondary Metabolites; Alkaloid biosynthesis I; map00950

Biosynthesis of Secondary Metabolites; Indole and ipecac alkaloid biosynthesis; map00901

Amino Acid Metabolism; Tyrosine metabolism; map00350

Organisms

Rat (10116)

Genome localization

14q21[24311 ],

Comments

A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan.

Rate-limiting Description

"The central hypothesis of this study is that coexpression of four dopamine biosynthetic and transporter genes in striatal neurons can support the efficient production and regulated, vesicular release of dopamine: tyrosine hydroxylase (TH) converts tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), GTP cyclohydrolase I (GTP CH I) is the rate-limiting enzyme in the biosynthesis of the cofactor for TH, aromatic amino acid decarboxylase (AADC) converts L-DOPA to dopamine, and a vesicular monoamine transporter (VMAT-2) transports dopamine into synaptic vesicles, thereby supporting regulated, vesicular release of dopamine and relieving feedback inhibition of TH by dopamine." (15684695)

"Three enzymes are necessary for efficient dopamine synthesis: tyrosine hydroxylase (TH) converts tyrosine to L-DOPA, aromatic L-amino acid decarboxylase (AADC) then converts L-DOPA to dopamine, and guanosine triphosphate cyclohydrolase I (GCH) is the rate-limiting enzyme for the synthesis of TH co-factor tetrahydrobiopterine." (12235825)

"In tubules preincubated with inhibitors of aromatic amino acid decarboxylase (AADC), the rate-limiting enzyme in renal dopamine formation, prolactin had no effect on Na(+), K(+)-ATPase activity." (16164646)

"Tyrosine hydroxylation, the rate-limiting step in CA synthesis, was assessed by measuring the accumulation of 3,4-dihydroxyphenyalanine (DOPA) by high pressure liquid chromatography coupled to electrochemical detection (HPLC-EC) in rat striatal dices following incubation of the tissue with the aromatic L-amino acid decarboxylase inhibitor m-hydroxybenzyl hydrazine (NSD 1015)." (15927700)

Gene ontology

Gene ontology

GO:0030170 (F) pyridoxal phosphate binding [P14173 ];
GO:0004058 (F) aromatic-L-amino-acid decarboxylase activity [P14173 ];
GO:0019752 (P) carboxylic acid metabolic process [P14173 ];
GO:0042423 (P) catecholamine biosynthetic process [P14173 ];

Links

SwissProt

P14173

Entrez Gene

24311



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  Last Modified: 2009-03-24  
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