Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

6.4.1.2

Official Name

acetyl-CoA carboxylase

Name from literature

acetyl CoA carboxylase

Pathway from literature

the de novo synthesis of lipids and cholesterol

Pathway from KEGG

Biosynthesis of Secondary Metabolites; Tetracycline biosynthesis; map00253

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Carbohydrate Metabolism; Propanoate metabolism; map00640

Lipid Metabolism; Fatty acid biosynthesis; map00061

Organisms

Mouse (10090)

Genome localization

5 F[100705 ], 11 C[107476 ],

Comments

A biotinyl-protein. Also catalyses transcarboxylation; the plant enzyme also carboxylates propanonyl-CoA and butanoyl-CoA.

Rate-limiting Description

"However, since it is unknown whether peroxisome proliferators have an effect on biosynthesis of fatty acid or not, we commenced to study if acetyl-CoA carboxylase, the rate-limiting enzyme of fatty acid biosynthesis, is inhibited by 2-(p-chlorophenoxy)-2-methylpropionic acid or 2-ethylhexanoic acid which is a typical peroxisome proliferator." (8938993)

Regulatory Information

Upstream transcription factor

19016

Regulatory type

Detail

phosphorylation;

Q5SWU9

transcriptional factor;PPARgamma(19016)

"when fed fat-free diet for 10 days, there was significant up-regulation of PPARgamma and several enzymes in the lipogenic pathway in the liver of liver-specific ACC1 knockout mice compared with the WT mice" (16717184)

Gene ontology

Gene ontology

GO:0030145 (F) manganese ion binding [Q5SWU9 ];
GO:0009374 (F) biotin binding [Q5SWU9 ];
GO:0004075 (F) biotin carboxylase activity [Q5SWU9 ];
GO:0003989 (F) acetyl-CoA carboxylase activity [Q5SWU9 ];
GO:0005737 (C) cytoplasm [Q5SWU9 ];
GO:0006633 (P) fatty acid biosynthetic process [Q5SWU9 ];
GO:0005524 (F) ATP binding [Q5SWU9 ];

Subcellular localization

Localization

cytoplasm [Q5SWU9 ];

Links

SwissProt

Q5SWU9

Entrez Gene

100705; 107476



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  Last Modified: 2009-03-24  
  Design by Zhao Min