Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.14.13.9

Official Name

kynurenine 3-monooxygenase

Name from literature

l kynurenine hydroxylase

Pathway from literature

tryptophan-NAD pathway in Saccharomyces carlsbergensis

Pathway from KEGG

Amino Acid Metabolism; Tryptophan metabolism; map00380

Organisms

Rat (10116)

Genome localization

13q25[59113 ],

Comments

A flavoprotein (FAD).

Rate-limiting Description

"As kynurenine 3-hydroxylase is reported to be a rate-limiting enzyme in the tryptophan-NAD pathway in rats, branched chain amino acids, branched chain alpha-keto acids and several other keto acids were tested for their effects on kynurenine 3-hydroxylase activity in the mitochondrial outer membrane fraction prepared from rat liver." (7131097)

Regulatory Information

Regulatory type

Detail

phosphorylation;

O88867:from_uniprot:399_Phosphothreonine

Gene ontology

Gene ontology

GO:0016021 (C) integral to membrane [O88867 ];
GO:0004502 (F) kynurenine 3-monooxygenase activity [O88867 ];
GO:0055114 (P) oxidation reduction [O88867 ];
GO:0005741 (C) mitochondrial outer membrane [O88867 ];

Subcellular localization

Localization

mitochondrion [O88867 ];

Links

SwissProt

O88867

Entrez Gene

59113



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  Last Modified: 2009-03-24  
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