Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

6.2.1.1

Official Name

acetate---CoA ligase

Name from literature

cytoplasmic acetyl coenzyme A [CoA] synthetase

Pathway from literature

the de novo synthesis of lipids and cholesterol

Pathway from KEGG

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Carbohydrate Metabolism; Propanoate metabolism; map00640

Energy Metabolism; Reductive carboxylate cycle (CO2 fixation); map00720

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Organisms

Mouse (10090)

Genome localization

2 H2[60525 ], 2 G3[68738 ],

Comments

Also acts on propanoate and propenoate.

Rate-limiting Description

"Enzymes likely to be rate limiting to this process include acetyl CoA carboxylase, fatty acid synthetase, acetyl CoA synthetase, and/or pyruvate dehydrogenase." (2902801)

Regulatory Information

Upstream transcription factor

12606

Regulatory type

Detail

phosphorylation;

Q9QXG4:from_uniprot:263_Phosphoserine

phosphorylation;

Q9QXG4:from_uniprot:267_Phosphoserine

phosphorylation;

Q9QXG4:from_uniprot:30_Phosphoserine

transcriptional factor;C/EBPalpha(12606)

"Transcriptional regulation of ketone body-utilizing enzyme, acetoacetyl-CoA synthetase, by C/EBPalpha during adipocyte differentiation." (18514076)

Gene ontology

Gene ontology

GO:0016208 (F) AMP binding [Q9QXG4, Q99NB1 ];
GO:0005759 (C) mitochondrial matrix [Q99NB1 ];
GO:0005739 (C) mitochondrion [Q14DH7 ];
GO:0005737 (C) cytoplasm [Q9QXG4 ];
GO:0006085 (P) acetyl-CoA biosynthetic process [Q9QXG4, Q99NB1 ];
GO:0003987 (F) acetate-CoA ligase activity [Q9QXG4, Q14DH7, Q99NB1 ];
GO:0008152 (P) metabolic process [Q14DH7 ];

Subcellular localization

Localization

mitochondrion [Q14DH7, Q99NB1 ];

cytoplasm [Q9QXG4 ];

Links

SwissProt

Q14DH7; Q99NB1; Q9QXG4

Entrez Gene

60525; 68738



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min