2.3.3.8

ATP citrate synthase

citrate lyase

de novo synthesis of fatty acids and triglycerides

Mouse (10090)

11 D[104112 ],

The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate---CoA ligase).

"This phenotype is caused by a mild but significant reduction in total energy expenditure paralleled by increased expression of ATP citrate lyase, a rate-limiting step in de novo synthesis of fatty acids and triglycerides." (17404227)

20787

phosphorylation;

phosphorylation;

phosphorylation;

phosphorylation;

transcriptional factor;SREBP1a(20787)

"The roles of sterol regulatory element-binding proteins in the transactivation of the rat ATP citrate-lyase promoter." (10801800#11750882)

GO:0000287 (F) magnesium ion binding [Q91V92 ];
GO:0008610 (P) lipid biosynthetic process [Q91V92 ];
GO:0004775 (F) succinate-CoA ligase (ADP-forming) activity [Q91V92 ];
GO:0005737 (C) cytoplasm [Q91V92 ];
GO:0005524 (F) ATP binding [Q91V92 ];
GO:0044262 (P) cellular carbohydrate metabolic process [Q91V92 ];
GO:0003878 (F) ATP citrate synthase activity [Q91V92 ];
GO:0005515 (F) protein binding [Q91V92 ];
GO:0006085 (P) acetyl-CoA biosynthetic process [Q91V92 ];

cytoplasm [Q91V92 ];

Q91V92

104112