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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 2.3.3.8 |
Official Name | ATP citrate synthase |
Name from literature | citrate lyase |
Pathway from literature | de novo synthesis of fatty acids and triglycerides |
Pathway from KEGG |
Energy Metabolism; Reductive carboxylate cycle (CO2 fixation); map00720 |
Carbohydrate Metabolism; Citrate cycle (TCA cycle); map00020 | |
Organisms | Mouse (10090) |
Genome localization | 11 D[104112 ], |
Comments | The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate---CoA ligase). |
Rate-limiting Description | "This phenotype is caused by a mild but significant reduction in total energy expenditure paralleled by increased expression of ATP citrate lyase, a rate-limiting step in de novo synthesis of fatty acids and triglycerides." (17404227) |
Regulatory Information |
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Upstream transcription factor | |
Regulatory type | Detail |
phosphorylation; | Q91V92:from_uniprot:1090_Phosphoserine |
phosphorylation; | Q91V92:from_uniprot:131_Phosphotyrosine |
phosphorylation; | Q91V92:from_uniprot:455_Phosphoserine; by PKA |
phosphorylation; | Q91V92:from_uniprot:672_Phosphotyrosine |
transcriptional factor;SREBP1a(20787) | "The roles of sterol regulatory element-binding proteins in the transactivation of the rat ATP citrate-lyase promoter." (10801800#11750882) |
Gene ontology |
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Gene ontology |
GO:0000287 (F) magnesium ion binding [Q91V92 ]; |
Subcellular localization |
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Localization |
cytoplasm [Q91V92 ]; |
Links |
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SwissProt | |
Entrez Gene |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |