Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.5.1.61

Official Name

hydroxymethylbilane synthase

Name from literature

uroporphyrinogen synthase

Pathway from literature

porphyrin synthesis

Pathway from KEGG

Metabolism of Cofactors and Vitamins; Porphyrin and chlorophyll metabolism; map00860

Organisms

Yeast (4932)

Genome localization

-[851322 ],

Comments

The enzyme works by stepwise addition of pyrrolylmethyl groups until a hexapyrrole is present at the active centre. The terminal tetrapyrrole is then hydrolysed to yield the product, leaving a cysteine-bound dipyrrole on which assembly continues. In the presence of a second enzyme, EC 4.2.1.75 uroporphyrinogen-III synthase, which is often called cosynthase, the product is cyclized to form uroporphyrinogen-III. If EC 4.2.1.75 is absent, the hydroxymethylbilane cyclizes spontaneously to form uroporphyrinogen I.

Rate-limiting Description

"In an attempt to identify rate-limiting steps in heme synthesis, which may constitute potential regulatory points, we constructed yeast strains overproducing two enzymes of the pathway: the porphobilinogen synthase (PBG-S) and deaminase (PBG-D)." (14559249)

Gene ontology

Gene ontology

GO:0004418 (F) hydroxymethylbilane synthase activity [P28789 ];
GO:0006783 (P) heme biosynthetic process [P28789 ];
GO:0005634 (C) nucleus [P28789 ];
GO:0005737 (C) cytoplasm [P28789 ];

Links

SwissProt

P28789

Entrez Gene

851322



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  Last Modified: 2009-03-24  
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