Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.1

Official Name

hexokinase

Name from literature

hexokinase

Pathway from literature

glycolysis

Pathway from KEGG

Carbohydrate Metabolism; Starch and sucrose metabolism; map00500

Carbohydrate Metabolism; Aminosugars metabolism; map00530

Carbohydrate Metabolism; Fructose and mannose metabolism; map00051

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Carbohydrate Metabolism; Galactose metabolism; map00052

Biosynthesis of Secondary Metabolites; Streptomycin biosynthesis; map00521

Organisms

Mouse (10090)

Genome localization

6 C3|6 34.5 cM[15277 ], 13 B1[212032 ], 10 B4|10 30.0 cM[15275 ],

Comments

D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.

Rate-limiting Description

"This enzyme mediates the rate-limiting step in brain glucose metabolism, namely the intracellular conversion of glucose to glucose-6-phosphate." (8375589)

"Hexokinase II is primarily expressed in muscle and adipose tissues where it catalyzes the phosphorylation of glucose to glucose 6-phosphate, a possible rate-limiting step for glucose disposal." (10428828)

Regulatory Information

Upstream transcription factor

20787

Regulatory type

Detail

phosphorylation;

O08528

phosphorylation;

Q3TRM8

phosphorylation;

O08528:from_uniprot:461_Phosphotyrosine

phosphorylation;

P17710:from_uniprot:83_Phosphotyrosine

phosphorylation;

Q3TRM8:from_uniprot:732_Phosphothreonine

transcriptional factor;SREBP1(20787)

"sterol regulatory element binding factor 1 plays a major role in the response of FAS and hexokinase 2 genes to nutritional regulation" (15627654)

Gene ontology

Gene ontology

GO:0046835 (P) carbohydrate phosphorylation [O08528 ];
GO:0004396 (F) hexokinase activity [P17710, O89063, O08528, Q3TRM8, Q91W97 ];
GO:0006096 (P) glycolysis [P17710, O89063, O08528, Q3TRM8, Q91W97 ];
GO:0005829 (C) cytosol [P17710 ];
GO:0005741 (C) mitochondrial outer membrane [P17710 ];
GO:0005524 (F) ATP binding [P17710, O89063, O08528, Q3TRM8, Q91W97 ];

Subcellular localization

Localization

mitochondrion [P17710 ];

membrane [P17710 ];

Links

SwissProt

O08528; O89063; P17710; Q3TRM8; Q91W97

Entrez Gene

15275; 15277; 212032



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min