Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.2.4.2/2.3.1.61/1.8.1.4

Official Name

dihydrolipoyllysine-residue succinyltransferase

Name from literature

oxoglutarate dehydrogenase complex

Pathway from literature

citric acid cycle

Pathway from KEGG

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Carbohydrate Metabolism; Citrate cycle (TCA cycle); map00020

Amino Acid Metabolism; Tryptophan metabolism; map00380

Amino Acid Metabolism; Glycine, serine and threonine metabolism; map00260

Amino Acid Metabolism; Valine, leucine and isoleucine degradation; map00280

Amino Acid Metabolism; Lysine degradation; map00310

Amino Acid Metabolism; Alanine and aspartate metabolism; map00252

Organisms

Mouse (10090)

Genome localization

12 D3[78920 ], 12 A3|12 15.1 cM[13382 ], 14 B[239017 ], 11 A1[18293 ],

Comments

A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalysed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A.

Rate-limiting Description

"The measured rate of glutamine transport into the cells approximated to the metabolic flux and is suggested as a rate-limiting step." (8267405)

"The 2-oxoglutarate dehydrogenase complex (OGHDC) (also known as the alpha-ketoglutarate dehydrogenase complex) is a rate-limiting enzyme in the mitochondrial Krebs cycle." (15466852)

Gene ontology

Gene ontology

GO:0050660 (F) FAD binding [Q3TIE8, O08749 ];
GO:0006096 (P) glycolysis [Q60597, A2ATU0 ];
GO:0034602 (F) oxoglutarate dehydrogenase (NAD+) activity [Q60597 ];
GO:0005737 (C) cytoplasm [Q3TIE8 ];
GO:0045252 (C) oxoglutarate dehydrogenase complex [Q9D2G2 ];
GO:0004148 (F) dihydrolipoyl dehydrogenase activity [Q3TIE8, O08749 ];
GO:0031405 (F) lipoic acid binding [Q9D2G2 ];
GO:0006099 (P) tricarboxylic acid cycle [Q9D2G2 ];
GO:0009055 (F) electron carrier activity [Q3TIE8, O08749 ];
GO:0045454 (P) cell redox homeostasis [Q3TIE8, O08749 ];
GO:0042391 (P) regulation of membrane potential [O08749 ];
GO:0004591 (F) oxoglutarate dehydrogenase (succinyl-transf... [Q60597, A2ATU0 ];
GO:0030976 (F) thiamin pyrophosphate binding [Q60597, A2ATU0 ];
GO:0031966 (C) mitochondrial membrane [Q60597 ];
GO:0006508 (P) proteolysis [O08749 ];
GO:0005739 (C) mitochondrion [A2ATU0, Q9D2G2 ];
GO:0048240 (P) sperm capacitation [O08749 ];
GO:0006120 (P) mitochondrial electron transport, NADH to u... [O08749 ];
GO:0019861 (C) flagellum [O08749 ];
GO:0007369 (P) gastrulation [O08749 ];
GO:0005759 (C) mitochondrial matrix [Q60597, O08749 ];
GO:0043159 (C) acrosomal matrix [O08749 ];
GO:0055114 (P) oxidation reduction [Q60597, A2ATU0, Q3TIE8 ];
GO:0004149 (F) dihydrolipoyllysine-residue succinyltransfe... [Q9D2G2 ];

Subcellular localization

Localization

mitochondrion [Q60597, A2ATU0, Q9D2G2, O08749 ];

Links

SwissProt

A2ATU0; Q60597; O08749; Q3TIE8; Q9D2G2

Entrez Gene

18293; 239017; 13382; 78920



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min