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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 1.2.1.70 |
Official Name | glutamyl-tRNA reductase |
Name from literature | glutamyl tRNA reductase |
Pathway from literature | heme biosynthesis |
Pathway from KEGG |
Metabolism of Cofactors and Vitamins; Porphyrin and chlorophyll metabolism; map00860 |
Organisms | E.coli (83333) |
Genome localization | -[945777 ], |
Comments | This enzyme forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway. The route shown in the diagram is used in most eubacteria, and in all archaebacteria, algae and plants. However, in the alpha-proteobacteria, EC 2.3.1.37, 5-aminolevulinate synthase, is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic alpha-proteobacterium. Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37. |
Rate-limiting Description | "In the present work, we construct the helper plasmid pHg expressing glutamyl-tRNA reductase (hemA) a key enzyme catalyzing the rate-limiting reaction in heme biosynthesis in E." (16122943) |
Gene ontology |
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Gene ontology |
GO:0050661 (F) NADP binding [P0A6X1 ]; |
Links |
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SwissProt | |
Entrez Gene |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |