1.2.1.70

glutamyl-tRNA reductase

glutamyl tRNA reductase

heme biosynthesis

E.coli (83333)

-[945777 ],

This enzyme forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway. The route shown in the diagram is used in most eubacteria, and in all archaebacteria, algae and plants. However, in the alpha-proteobacteria, EC 2.3.1.37, 5-aminolevulinate synthase, is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic alpha-proteobacterium. Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37.

"In the present work, we construct the helper plasmid pHg expressing glutamyl-tRNA reductase (hemA) a key enzyme catalyzing the rate-limiting reaction in heme biosynthesis in E." (16122943)

GO:0050661 (F) NADP binding [P0A6X1 ];
GO:0004764 (F) shikimate 5-dehydrogenase activity [P0A6X1 ];
GO:0055114 (P) oxidation reduction [P0A6X1 ];
GO:0008883 (F) glutamyl-tRNA reductase activity [P0A6X1 ];
GO:0006779 (P) porphyrin biosynthetic process [P0A6X1 ];
GO:0005737 (C) cytoplasm [P0A6X1 ];

P0A6X1

945777