Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.2.1.70

Official Name

glutamyl-tRNA reductase

Name from literature

glutamyl tRNA reductase

Pathway from literature

heme biosynthesis

Pathway from KEGG

Metabolism of Cofactors and Vitamins; Porphyrin and chlorophyll metabolism; map00860

Organisms

E.coli (83333)

Genome localization

-[945777 ],

Comments

This enzyme forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway. The route shown in the diagram is used in most eubacteria, and in all archaebacteria, algae and plants. However, in the alpha-proteobacteria, EC 2.3.1.37, 5-aminolevulinate synthase, is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic alpha-proteobacterium. Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37.

Rate-limiting Description

"In the present work, we construct the helper plasmid pHg expressing glutamyl-tRNA reductase (hemA) a key enzyme catalyzing the rate-limiting reaction in heme biosynthesis in E." (16122943)

Gene ontology

Gene ontology

GO:0050661 (F) NADP binding [P0A6X1 ];
GO:0004764 (F) shikimate 5-dehydrogenase activity [P0A6X1 ];
GO:0055114 (P) oxidation reduction [P0A6X1 ];
GO:0008883 (F) glutamyl-tRNA reductase activity [P0A6X1 ];
GO:0006779 (P) porphyrin biosynthetic process [P0A6X1 ];
GO:0005737 (C) cytoplasm [P0A6X1 ];

Links

SwissProt

P0A6X1

Entrez Gene

945777



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  Last Modified: 2009-03-24  
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