1.1.3.8

L-gulonolactone oxidase

l gulono lactone oxidase

ascorbate synthesis

Mouse (10090)

14 D1[268756 ],

A microsomal flavoprotein (FAD). The product spontaneously isomerizes to L-ascorbate. While most higher animals can synthesize asborbic acid, primates and guinea pigs cannot [3].

"When mice deficient in L-gulono-gamma-lactone oxidase (Gulo(-/-)), the rate-limiting enzyme in ascorbate synthesis, were depleted of ascorbate and infected with K." (16632110)

"LPS decreased gulonolactone oxidase activity, which is rate-limiting for de novo synthesis of ascorbate from glucose, but increased the rate of DHAA reduction to ascorbate." (16177205)

GO:0050660 (F) FAD binding [P58710 ];
GO:0003885 (F) D-arabinono-1, 4-lactone oxidase activity [P58710 ];
GO:0019853 (P) L-ascorbic acid biosynthetic process [P58710 ];
GO:0005789 (C) endoplasmic reticulum membrane [P58710 ];
GO:0050105 (F) L-gulonolactone oxidase activity [P58710 ];
GO:0009055 (F) electron carrier activity [P58710 ];
GO:0016021 (C) integral to membrane [P58710 ];
GO:0005792 (C) microsome [P58710 ];
GO:0055114 (P) oxidation reduction [P58710 ];

endoplasmic reticulum [P58710 ];

microsome [P58710 ];

P58710

268756