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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 1.1.3.8 |
Official Name | L-gulonolactone oxidase |
Name from literature | l gulono lactone oxidase |
Pathway from literature | ascorbate synthesis |
Pathway from KEGG |
Carbohydrate Metabolism; Ascorbate and aldarate metabolism; map00053 |
Organisms | Mouse (10090) |
Genome localization | 14 D1[268756 ], |
Comments | A microsomal flavoprotein (FAD). The product spontaneously isomerizes to L-ascorbate. While most higher animals can synthesize asborbic acid, primates and guinea pigs cannot [3]. |
Rate-limiting Description | "When mice deficient in L-gulono-gamma-lactone oxidase (Gulo(-/-)), the rate-limiting enzyme in ascorbate synthesis, were depleted of ascorbate and infected with K." (16632110) |
| "LPS decreased gulonolactone oxidase activity, which is rate-limiting for de novo synthesis of ascorbate from glucose, but increased the rate of DHAA reduction to ascorbate." (16177205) |
Gene ontology |
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Gene ontology |
GO:0050660 (F) FAD binding [P58710 ]; |
Subcellular localization |
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Localization | |
Links |
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SwissProt | |
Entrez Gene |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |