Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.3.8

Official Name

L-gulonolactone oxidase

Name from literature

l gulono lactone oxidase

Pathway from literature

ascorbate synthesis

Pathway from KEGG

Carbohydrate Metabolism; Ascorbate and aldarate metabolism; map00053

Organisms

Mouse (10090)

Genome localization

14 D1[268756 ],

Comments

A microsomal flavoprotein (FAD). The product spontaneously isomerizes to L-ascorbate. While most higher animals can synthesize asborbic acid, primates and guinea pigs cannot [3].

Rate-limiting Description

"When mice deficient in L-gulono-gamma-lactone oxidase (Gulo(-/-)), the rate-limiting enzyme in ascorbate synthesis, were depleted of ascorbate and infected with K." (16632110)

"LPS decreased gulonolactone oxidase activity, which is rate-limiting for de novo synthesis of ascorbate from glucose, but increased the rate of DHAA reduction to ascorbate." (16177205)

Gene ontology

Gene ontology

GO:0050660 (F) FAD binding [P58710 ];
GO:0003885 (F) D-arabinono-1, 4-lactone oxidase activity [P58710 ];
GO:0019853 (P) L-ascorbic acid biosynthetic process [P58710 ];
GO:0005789 (C) endoplasmic reticulum membrane [P58710 ];
GO:0050105 (F) L-gulonolactone oxidase activity [P58710 ];
GO:0009055 (F) electron carrier activity [P58710 ];
GO:0016021 (C) integral to membrane [P58710 ];
GO:0005792 (C) microsome [P58710 ];
GO:0055114 (P) oxidation reduction [P58710 ];

Subcellular localization

Localization

endoplasmic reticulum [P58710 ];

microsome [P58710 ];

Links

SwissProt

P58710

Entrez Gene

268756



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  Last Modified: 2009-03-24  
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