Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.3.10

Official Name

hydroxymethylglutaryl-CoA synthase

Name from literature

HMG CoA synthase

Pathway from literature

mevalonate pathway/ketogenesis

Pathway from KEGG

Amino Acid Metabolism; Valine, leucine and isoleucine degradation; map00280

Lipid Metabolism; Synthesis and degradation of ketone bodies; map00072

Carbohydrate Metabolism; Butanoate metabolism; map00650

Organisms

Rat (10116)

Genome localization

2q34[24450 ], 2q16[29637 ],

Rate-limiting Description

"The activity of the rate-limiting enzyme of liver ketone body production, hydroxymethylglutaryl CoA synthetase (HMG CoA synthetase), was not greatly influenced by training or exhuastive exercise indicating that the metabolic control of the ketosis of exercise may more likely be a function of the supply of fatty acids to the liver rather than the activity of HMG CoA synthetase." (475)

Regulatory Information

Upstream transcription factor

78968;300095;25747

Regulatory type

Detail

phosphorylation;

P17425

phosphorylation;

P17425:from_uniprot:495_Phosphoserine

phosphorylation;

P22791:from_uniprot:433_Phosphoserine

transcriptional factor;SREBP-2(300095),SREBP-1(78968)

"Sterol regulatory element binding protein-mediated effect of fluvastatin on cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase transcription." (10666309)

transcriptional factor;PPARalpha(25747)

"Hepatic mitochondrial outer membrane carnitine palmitoyltransferase I (CPT I) and mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMG-CoA synthase) enzymes play a key role in regulation of fatty acid oxidation and in ketogenic pathways, respectively. Their expression are regulated by fatty acids mainly by the peroxisome proliferator-activated receptor alpha (PPARalpha)." (15254779#11985831#11551854)

Gene ontology

Gene ontology

GO:0008299 (P) isoprenoid biosynthetic process [P22791, P17425 ];
GO:0005737 (C) cytoplasm [P17425 ];
GO:0004421 (F) hydroxymethylglutaryl-CoA synthase activity [P22791, P17425 ];
GO:0006695 (P) cholesterol biosynthetic process [P22791, P17425 ];

Subcellular localization

Localization

mitochondrion [P22791 ];

cytoplasm [P17425 ];

Links

SwissProt

P17425; P22791

Entrez Gene

24450; 29637



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  Last Modified: 2009-03-24  
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