Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.5

Official Name

arylamine N-acetyltransferase

Name from literature

N-acetyltransferase

Pathway from literature

melatonin synthesis

Pathway from KEGG

Xenobiotics Biodegradation and Metabolism; Drug metabolism - other enzymes; map00983

Biosynthesis of Secondary Metabolites; Caffeine metabolism; map00232

Xenobiotics Biodegradation and Metabolism; Trinitrotoluene degradation; map00633

Organisms

Mouse (10090)

Genome localization

8 B3.3|8 31.0 cM[17962 ], 8 B3.1|8 31.0 cM[17961 ], 8 B3.1|8 31.0 cM[17960 ],

Comments

Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA.

Rate-limiting Description

"The synthesis of melatonin is regulated by a rate-limiting enzyme, serotonin N-acetyltransferase (NAT)." (9597751)

"We recently demonstrated that stimulation of beta-adrenergic receptors only increases nighttime arylalkylamine N-acetyltransferase (Aa-Nat, the rate-limiting enzyme in melatonin synthesis) mRNA levels in mouse pineal gland in vitro, which suggests that pineal clocks may gate Aa-Nat gene expression." (16842546)

"The enzyme serotonin N-acetyltransferase (NAT) catalyzes the rate limiting step in melatonin synthesis." (8943074)

"The primary structure of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT: the rate-limiting enzyme in melatonin synthesis) in the mouse retina was deduced from the cDNA nucleotide sequence." (9708862)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P50295

phosphorylation;

P50295:from_uniprot:246_Phosphotyrosine

transcriptional level;Sp1

"Ubiquitously expressed transcripts of human NAT1 and its orthologue, murine Nat2, are initiated from promoters with conserved Sp1 elements." (16257833#12904181)

transcriptional level;

"Characterization of a hormone response element in the mouse N-acetyltransferase 2 (Nat2*) promoter." (9572394)

Gene ontology

Gene ontology

GO:0015807 (P) L-amino acid transport [P50296 ];
GO:0004060 (F) arylamine N-acetyltransferase activity [Q546L3, P50296, P50294, P50295, Q78ZC4, Q546K5 ];
GO:0015179 (F) L-amino acid transmembrane transporter acti... [P50296 ];
GO:0005886 (C) plasma membrane [P50296 ];
GO:0005737 (C) cytoplasm [P50296, P50294, P50295 ];
GO:0008152 (P) metabolic process [Q546L3, P50296, P50294, P50295, Q78ZC4, Q546K5 ];

Subcellular localization

Localization

cytoplasm [P50296, P50294, P50295 ];

Links

SwissProt

P50294; P50295; P50296; Q546K5; Q546L3; Q78ZC4

Entrez Gene

17960; 17961; 17962



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  Last Modified: 2009-03-24  
  Design by Zhao Min