Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.13.11.34

Official Name

arachidonate 5-lipoxygenase

Name from literature

oxygen oxidoreductase

Pathway from literature

leukotriene synthesis/first step in the pathway,but the conversion of LTA4 to LTB4

Pathway from KEGG

Lipid Metabolism; Linoleic acid metabolism; map00591

Lipid Metabolism; Arachidonic acid metabolism; map00590

Organisms

Mouse (10090)

Genome localization

6 F1|6 53.2 cM[11689 ],

Rate-limiting Description

"5-Lipoxygenase (5-LO) is the rate-limiting enzyme in leukotriene synthesis and was among the chromosome 6 locus candidate genes that we examined." (12142344)

Regulatory Information

Upstream transcription factor

20687;20683;19016

Regulatory type

Detail

phosphorylation;

P48999

phosphorylation;

P48999:from_uniprot:272_Phosphoserine

phosphorylation;

P48999:from_uniprot:524_Phosphoserine

transcriptional factor;"Sp1(20683),Sp3(20687)"

"we cloned approximately 2,000 bp of the mouse promoter sequence.Like the human promoter, the mouse Alox5 promoter lacks a TATA box and has multiple start sites. We show that Sp1/Sp3 is essential for constitutive promoter-reporter activity." (11919084)

others;

"Metabolites of this enzyme are involved in cyclic AMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression" (12943700)

transcriptional factor;PPARgamma(19016)

"PPARgamma-regulated gene expression and that 5-LO production of certain proinflammatory leukotrienes have the ability to diminish experimental allergic encephalomyelitis" (15328042)

Gene ontology

Gene ontology

GO:0016165 (F) lipoxygenase activity [P48999 ];
GO:0006954 (P) inflammatory response [P48999 ];
GO:0016020 (C) membrane [P48999 ];
GO:0004051 (F) arachidonate 5-lipoxygenase activity [P48999 ];
GO:0019370 (P) leukotriene biosynthetic process [P48999 ];
GO:0005737 (C) cytoplasm [P48999 ];
GO:0005506 (F) iron ion binding [P48999 ];
GO:0005509 (F) calcium ion binding [P48999 ];
GO:0005634 (C) nucleus [P48999 ];
GO:0055114 (P) oxidation reduction [P48999 ];

Subcellular localization

Localization

cell membrane [P48999 ];

cytoplasm [P48999 ];

Links

SwissProt

P48999

Entrez Gene

11689



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  Last Modified: 2009-03-24  
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